水杨酸甲酯立方液晶的研制  

Preparation of cubic liquid crystal as a drug delivery system for methylsalicylate

作　　者：吴晓晴[1] 桂双英[1,2,3] 陈玉林[1] 吴星星[1] 

机构地区：[1]安徽中医药大学,合肥230031 [2]安徽省中医药科学院药物制剂研究所,合肥230031 [3]安徽省中药制剂工程技术中心,合肥230031

出　　处：《中国新药杂志》2015年第7期837-840,共4页Chinese Journal of New Drugs

基　　金：国家自然科学基金(81274099);安徽省自然科学基金(11040606M219);安徽高校省级自然科学研究项目(KJ2012A184)

摘　　要：目的：制备水杨酸甲酯立方液晶并对其进行表征,同时建立水杨酸甲酯含量测定方法。方法：以植烷三醇为基质材料,采用自乳化方法制备水杨酸甲酯立方液晶;用偏光显微镜及小角衍射（SAXS）对立方液晶进行表征;采用HPLC测定立方液晶中水杨酸甲酯的含量。结果：立方液晶在偏光显微镜下视野黑暗;小角衍射显示在1.46,1.79,2.05,2.50处出现信号峰,其比值q1∶q2∶q3∶q4=21/2∶31/2∶41/2∶61/2,即为立方相液晶,其内部结构为Pn3m（Q224）双菱形晶格。水杨酸甲酯在0.99~198.12μg·mL-1呈良好线性关系（r=0.999）,平均回收率为99.89%,RSD为0.58%。结论：偏光显微镜及小角X射线衍射适于立方液晶的表征,高效液相测定方法简便、可行。Objective： To prepare and characterize cubic liquid crystalline as drug delivery systems for methylsalicylate,and establish a method for determination of content of methylsalicylate. Methods： Cubic liquid crystal was prepared by self-emulsification of phytantriol in water; the liquid crystaline structure was confirmed by polarizing microscopy and small-angle X-ray diffraction; an HPLC method was developed to determine the content of methylsalicylate. Results： Cubic liquid crystalline showed dark background under polarizing microscopy. The values of the scattering vector q corresponding to the scattering peaks were 1. 46,1. 79,2. 05,and 2. 50,the ratio of q1∶ q2∶ q3∶ q4 was 21/2∶31/2∶41/2∶61/2,which was characteristic of cubic periodicity indicative of a diamond（ Q224）. The linear range of the calibration curve for methylsalicylate was 0. 99 ~ 198. 12 μg·m L- 1（ r = 0. 999）,the average recovery of methylsalicylate was 99. 89% with RSD of 0. 58%. Conclusion： Polarizing microscopy and small-angle X-ray diffraction can be used to characterize cubic liquid crystalline. This determination method is convenient,accurate,and reproducible,which provides a determination method of methylsalicylate content.

关 键 词：立方液晶 水杨酸甲酯 偏光显微镜 小角X射线衍射 含量测定 

分 类 号：R971[医药卫生—药品]