高脂低蛋白饮食对大鼠肝功能的影响  

Effect on Liver Function of Rats with High-fat and Low-protein Diet

作　　者：韩旭[1] 韩冰冰[1] 高洁[1] 崔宁[1] 赵文晓[1] 刘黎青[1] 

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《中医药信息》2015年第2期60-62,共3页Information on Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助课题(No.2013CB531803)

摘　　要：目的:研究高脂低蛋白饮食对大鼠肝功能的影响。方法:用高脂低蛋白饮食喂养大鼠,检测大鼠血清中的AST、ALT、AST/ALT、CHE、TP、ALB、GLB、A/G、CHOL、TG、HDL-C、LDL-C含量的变化。结果:与空白对照组相对比,高脂低蛋白饮食组大鼠血清ALT含量降低(P<0.05);CHE、TP、ALB、GLB、A/G、CHOL、TG、HDL-C含量也均显著下降(P<0.01),差异具有显著性;LDL-C含量上升(P<0.05),AST/ALT值也明显增高(P<0.01),差异具有显著性。结论:高脂低蛋白饮食会对肝功能造成损伤。Objective ： To explore the effect on liver function of rats with high - fat and low - protein diet. Meth- ods： Adopt the diet of high -fat and low -protein to feed the rats. Test serum AST, ALT, AST/ALT, CHE, TP, ALB, GLB, A/G, CHOL, TG, HDL - C, LDL - C contents. Results： Compared with the control group, serum ALT content of rats in high - fat and low - protein diet group tended to decrease （ P 〈 0.05 ） ; serum CHE, TP, ALB, GLB, A/G, CHOL, TG, HDL - C contents of rats in high - fat and low - protein diet group also tended to decrease significantly （P 〈0.01 ） ; serum LDL- C contents of rats in high-fat and low- pro- tein diet group tended to increase （ P 〈 0.05 ） ; serum AST/ALT content of rats in high - fat and low - protein diet group also tended to increase significantly （P 〈0.01 ）. Conclusion：High- fat and low- protein diet has damaged liver functions,

关 键 词：高脂低蛋白 大鼠 肝脏 

分 类 号：R285.5[医药卫生—中药学]