自拟湿热消汤治疗ⅢA型慢性前列腺炎的临床疗效观察及对前列腺液炎性因子的影响  

Study on Clinical Effect of Shirexiao Tang (湿热消汤) for Type IIIA Chronic Prostatitis and Impact on Inflammatory Cytokines in Prostatic Secretion

作　　者：张畅[1] 李琳[1] 陈波[1] 钟景琦[1] 

机构地区：[1]上海交通大学医学院附属同仁医院,上海200336

出　　处：《中国中医药科技》2015年第2期139-140,181,共3页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:观察湿热消汤治疗ⅢA型慢性前列腺炎(CP)的临床疗效,及对前列腺液(EPS)炎性因子的影响。方法:将本院门诊收治的94例ⅢA型CP患者随机分为治疗组和对照组,各47例。对照组给予盐酸坦洛新缓释片和吲哚美辛肠溶片口服,治疗组在此基础上给予自拟湿热消汤治疗,两组均连用2个月。观察两组患者的临床疗效、前列腺炎症状指数(NIH-CPSI)评分及EPS中炎性因子的变化情况。结果:治疗组总有效率为87.2%,显著优于对照组66.0%(P<0.05);治疗组治疗后NIH-CPSI评分显著低于对照组(P<0.05);治疗后,两组EPS中各炎性因子水平均明显降低(P<0.05),治疗组IL-6、IL-8、TNF-α水平显著低于对照组(P<0.05)。结论:湿热消汤治疗ⅢA型CP标本兼治,能够改善前列腺组织炎症损伤。Objective： To explore clinical effect of Shirexiao Tang for type IIIA chronic prostatitis（ CP）,and analyze the impact on expression of inflammatory cytokines in prostatic secretion（ EPS）. Methods： 94 cases of type IIIA CP were randomly divided into two groups. The control group（ n = 47） was treated with tamsulosin hydrochloride and indomethacin orally,and treatment group（ n = 47） was treated with Shirexiao Tang additionally,all the patients were treated for 2 months. The clinical effect,NIH- CPSI score,inflammatory cytokines of EPS in the two groups after treatment were observed and compared. Results： The total effective rate in treatment group and control group respectively was 87. 2% and 66. 0%,it was statistically different（ P〈0. 05）. The NIH- CPSI score was significantly decreased in treatment group that were lower than those in control group after treatment（ P〈0. 05）. After treatment,inflammatory cytokines of EPS in both groups were all decreased,and treatment group had more remarkable increasemeat than those of control group in IL- 6,IL- 8,TNF- α levels（ P〈0. 05）. Conclusions： Shirexiao Tang can cure type IIIA CP and improve the inflammation injury of prostate tissue.

关 键 词：前列腺炎 慢性病 湿热下注型 湿热消汤 白细胞介素 肿瘤坏死因子 

分 类 号：R277.5[医药卫生—中医学]