参芪平糖宁对2型糖尿病胰岛素抵抗大鼠血脂和胰腺组织病理形态学变化的影响  

Effects of Shengqi Pingtangning (参芪平糖宁) on Blood Lipid and Pancreatic Pathological Changes in T2DM Rats with Insulin Resistance

作　　者：梁治学[1] 胡燕[1] 胡海燕[1] 李静雅[1] 李其忠[2] 周语平[3] 

机构地区：[1]甘肃平凉医学高等专科学校,平凉744000 [2]上海中医药大学,上海201203 [3]甘肃中医学院,兰州730000

出　　处：《中国中医药科技》2015年第2期171-172,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：甘肃省高等学校科研项目(2013B-134);甘肃省平凉市科研项目(200707)

摘　　要：目的:观察中药复方参芪平糖宁对2型糖尿病胰岛素抵抗大鼠血脂及胰腺组织病理形态学变化的影响。方法:采用链脲佐菌素腹腔注射加高脂高糖饮食复制2型糖尿病胰岛素抵抗大鼠模型,观察参芪平糖宁对其血脂含量和胰腺组织病理形态学的影响。结果:实验性2型糖尿病胰岛素抵抗大鼠在应用参芪平糖宁治疗后,血脂明显改善,胰腺组织病理学变化明显减轻,胰岛β细胞数量明显增加,与模型组比较有显著的统计学意义(P<0.05,P<0.01)。结论:参芪平糖宁能有效地调节2型糖尿病胰岛素抵抗大鼠脂代谢紊乱,提高胰岛β细胞数量,修复受损胰岛β细胞,从而防治糖尿病胰岛素抵抗。Objective： To investigate the effects of Shengqi Pingtangning（ SQPTN） on blood lipid and pancreatic pathological changes in type 2 diabetes mellitus（ T2DM） rats with insulin resistance. Methods： Adopting intraperitoneal injection of streptozocin and high caloric diet to induce rats＇ T2 DM with insulin resistance model,observed the effect of SQPTN on blood lipid and pancreatic pathological changes. Results： The blood lipid levels in SQPTN group rats were improved obviously,the pancreatic pathologic changes were alleviated significantly and β- cells count was increased,there was obvious difference to compare with those of model rats.（ P〈0. 01,P〈0 05）. Conclusion： SQPTN can treat T2 DM insulin resistance by regulating blood lipid disorder and recover β- cells injury.

关 键 词：糖尿病 非胰岛素依赖型 参芪平糖宁 胰岛素抵抗 胰岛素敏感性 病理形态学 大鼠 

分 类 号：R285.5[医药卫生—中药学]