参芪平糖宁对2型糖尿病胰岛素抵抗大鼠胰岛素敏感性和肿瘤坏死因子的影响  

Effects of Shengqi Pingtangning (参芪平糖宁) on Insulin Sensitivity and TNF-α Level in T2DM Rats with Insulin Resistance

作　　者：梁治学[1] 胡燕[1] 胡海燕[1] 李静雅[1] 李其忠[2] 周语平[3] 

机构地区：[1]甘肃平凉医学高等专科学校,平凉744000 [2]上海中医药大学,上海201203 [3]甘肃中医学院,兰州730000

出　　处：《中国中医药科技》2015年第2期173-174,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：甘肃省高等学校科研项目(2013B-134);甘肃省平凉市科研项目(200707)

摘　　要：目的:观察中药复方参芪平糖宁对2型糖尿病胰岛素抵抗大鼠胰岛素敏感性及肿瘤坏死因子的影响。方法:采用链脲佐菌素腹腔注射加高脂高糖饮食制备糖尿病胰岛素抵抗大鼠模型,观察参芪平糖宁对其血糖、胰岛素、胰岛素敏感指数、血清肿瘤坏死因子-α(TNF-α)含量的影响。结果:实验性糖尿病胰岛素抵抗大鼠在应用参芪平糖宁治疗后,高剂量组大鼠空腹血糖明显降低,胰岛素敏感指数明显升高,低高剂量组大鼠胰岛素含量明显增加,血清肿瘤坏死因子明显降低,与模型组比较均具统计学意义(P<0.05或P<0.01)。结论:参芪平糖宁能有效地降低2型糖尿病胰岛素抵抗大鼠血糖和胰岛素水平,提高胰岛素敏感性,降低肿瘤坏死因子含量,从而防治糖尿病胰岛素抵抗。Objective： To investigate the effects of Shengqi Pingtangning（ SQPTN） on insulin sensitivity and serum TNF- α level in diabetes mellitus（ DM） rats with insulin resistance. Methods： Adopting intraperitoneal injection of streptozocin and high caloric diet to induce DM rats with insulin resistance model,observing the effects of SQPTN on blood- glucose,insulin,insulin sensitive index and serum TNF- α level. Results： The blood glucose in high dosage SQPTN group was reduced obviously,insuline sensitive index was raised,serum insulin was increased in low and high dosage SQPTN groups and TNF- α contents in low and high dosage SQPTN groups were lowered significantly,there were significantl differene compared with those of model group（ P〈0. 01,P〈0. 05）. Conclusion： SQPTN can treat T2 DM insulin resistance by many ways and targets.

关 键 词：糖尿病 非胰岛素依赖型 参芪平糖宁 胰岛素抵抗 胰岛素敏感性 肿瘤坏死因子 大鼠 

分 类 号：R285.5[医药卫生—中药学]