肠道菌群与脑-肠轴功能相互影响的研究进展  

Advances in Study on Interaction between Gut Microbiota and Brain-gut Axis

作　　者：张璐[1] 刘懿萱[1] 段丽萍[1] 

机构地区：[1]北京大学第三医院消化科,100191

出　　处：《胃肠病学》2014年第9期563-565,共3页Chinese Journal of Gastroenterology

摘　　要：人体肠道内的菌群参与了许多生理功能的维持和疾病的发生。作为大脑和胃肠道功能相互调节的重要桥梁,脑-肠轴功能的正常发挥是肠道菌群维持稳定的条件。脑-肠轴紊乱可激活肠黏膜免疫,对肠道菌群产生影响,使菌群结构发生改变。反之,肠道菌群结构改变亦会影响神经系统发育,导致脑-肠轴功能紊乱,其中迷走神经和血清代谢物质在脑-肠轴功能的调节中发挥重要作用。本文就肠道菌群与脑-肠轴功能相互影响的研究进展作一综述。Gut microbiota plays an important role in the maintenance of physiological function and genesis of some gut diseases. Brain-gut axis,as an important link between brain and gastrointestinal tract,is a requisite of gut microbiota stability. The dysfunction of brain-gut axis may lead to intestinal dysbiosis through activation of intestinal immune activity. Conversely,intestinal dysbiosis can influence nervous system development and may cause dysfunction of brain-gut axis,in which vagus nerve and metabolites in serum may be the critical factors. This article reviewed the advances in study on interaction between gut microbiota and brain-gut axis.

关 键 词：肠道菌群 脑-肠轴 肠黏膜 迷走神经 

分 类 号：R333[医药卫生—人体生理学]