干燥综合征108例临床分析  

Clinical Analysis in 108 Patients with Sjgren's Syndrome

作　　者：张娜[1,2] 付学锋[1,2] 陈筱筱[1,2] 王美燕[1,2] 

机构地区：[1]浙江大学金华医院 [2]金华市中心医院皮肤科,浙江金华321000

出　　处：《中国皮肤性病学杂志》2015年第4期368-371,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的进一步了解干燥综合征(SS)的临床特征及其伴有的系统损害情况。方法回顾性分析本院2012年7月-2014年6月收治的108例SS患者的临床资料,包括临床表现、初始症状、脏器受累情况等。结果原发性SS 71例,其中男4例,女67例。继发性SS 37例,其中男2例,女35例。最常见的首发症状为口/眼干燥(32例,29.63%),其次为关节疼痛(25例,23.15%)等;易合并甲状腺疾病(38例,35.19%)、自身免疫性肝病(8例,7.41%)等。继发性SS最易合并类风湿性关节炎(17例,45.95%),其次为SLE 10例(27.03%)。Ig G升高49例(45.37%)、Ig A升高22例(20.37%)、Ig M升高16例(14.81%),抗SSA抗体阳性91例(84.26%),抗SSB阳性50例(46.30%)。97例行高分辨率CT检查的患者中,31例(31.96%)为间质性肺病;44例(40.74%)血红蛋白降低,28例(25.93%)白细胞降低,22例(20.37%)血小板降低。100例(92.59%)病情得到缓解,8例(7.41%)病情恶化,目前尚无死亡病例。结论 SS是一种慢性以多脏器损害为主要表现的系统性疾病,其临床表现多样,首诊科室不一,继发性SS患者因为原发病较多,掩盖了其初起症状,从而延误诊治。提示临床医生要做到早诊断,早治疗,警惕SS的系统损害,从而改善预后。Objective To analyze the clinical characteristics and systemic damage of primary and secondary SjoSgren＇s syndrome. Methods Clinical data of 108 patients with Sjogren＇s syndrome（SS） in the inpatient department of our hospital from July 2012 to June 2014 were collected and analyzed,including manifestations at onset, clinical characteristics and major organ involvement. Results Seventy-one cases of 108 SS were primary Sjogren＇s syndrome,including 4 male and 67 female. Thirty seven cases were secondary Sjogren＇s syndrome, including 2 male and 35 female. Dry eyes and mouth were reported as initial symptoms in 32 cases （29.63%） ,while joint pain was reported in 25 cases（23.15% ）. Thyroid diseases（TD） was reported as the complication in 38 cases（35. 19% ）, while autoimmune liver disease was reported in 8 cases （7.41%）. Rheumatoid arthritis（ 17 cases,45.95% ） followed by systemic lupus erythematosus （10 cases,27.03% ） were the most common complications of secondary Sjogren＇s syndrome （SS）. The elevation of IgG, IgA and IgM were noted in 49（45.37% ） ,22（20.37% ） and 16（ 14.81% ） cases respectively. The anti-SSA antibod- y and anti-SSB antibody were positive in 91 （84.26%） and 50（46.30% ） cases respectively. Interstitial lung disease was noted in 31 （31.96%） patients of 97 Sjogren＇s syndrome. Hematologic abnormity of hemoglobin, white blood cells and platelet occurred respectively in 44（40.74% ） ,28（25.93% ） and 22（20.37% ） ca- ses. One hundred （92.59 % ） patients reported improvement, and 8 （7.41%）of patients experienced worse- ning of the disease,and there were no deaths so far. Conclusion Sjogren＇s syndrome is a systemic disease with multiple organ dysfunction. Patients may visit different departments due to the diverse clinical manifesta- tions. Delayed diagnosis and treatment may be noted in patiens with sSS because of complicated primary dis- ease. Early diagnosis and treatment is necessary to avoid systemic damage and to i

关 键 词：干燥综合征 临床分析 抗SSA抗体 抗SSB抗体 系统性红斑狼疮 类风湿性关节炎 甲状腺疾病 

分 类 号：R442.8[医药卫生—诊断学]