依达拉奉对重型颅脑损伤患者血浆8-iso-PGF_(2α)水平的影响及其临床疗效观察  

Effect of edaravone on plasma level of 8-iso-prostaglandin-F_(2α) and prognosis in patients with severe craniocerebral trauma

作　　者：张斌[1] 钱春生[1] 

机构地区：[1]金坛市人民医院神经外科,江苏213200

出　　处：《中国临床神经外科杂志》2015年第3期153-154,186,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨依达拉奉对重型颅脑损伤(s TBI)患者血浆8-表氧前列腺素F2α(8-iso-PGF2α)水平的影响及其治疗s TBI的效果。方法将60例s TBI患者随机分为观察组和对照组,每组30例。两组均给予常规治疗,包括脱水降颅压、止血、抗感染、降血糖、营养药物及手术等。观察组在常规治疗基础上给予新型抗氧化剂依达拉奉(30 mg,静脉滴注,2次/d,持续2周)。治疗后2、3、7、14、30 d采用酶联免疫吸附法检测血浆8-iso-PGF2α水平。治疗后14 d进行GCS评分,治疗后3个月按照GOS评分评估患者预后。结果治疗后2 d,两组血浆8-iso-PGF2α水平均较治疗前显著升高(P<0.05),随后显著下降(P<0.05),观察组显著低于对照组((P<0.05)。治疗后14 d,两组GCS评分均明显高于治疗前(P<0.05),观察组明显高于对照组(P<0.05)。治疗后3个月,两组GOS评分均明显高于治疗前(P<0.05),观察组明显高于对照组(P<0.05)。结论应用依达拉奉可显著降低s TBI患者血浆8-iso-PGF2α水平,改善患者预后。Objective To explore the effects of endaravone on the prognoses and plasma level of 8-iso-prostaglandin-F2α（8-iso-PGF2 α） in the patients with severe craniocerebral trauma.MethodsSixty patients with severe craniocerebral trauma were randomlydivided into control group（n=30） and treatment group（n=30）. The patients in both the groups were given routine therapy includingdehydration, anti-inflammation, hemostasis, anti-infection, lowering the intracranial pressure, anti-diabetics treatment, nutritious drugsand surgeries. Based on this, 30 mg endaravone twice a day for was intravenously injected for 2 weeks, twice a day, in the treatmentgroup. The plasma levels of 8-iso- PGF2αwere determined before the treatment and 1, 2, 6, 13 and 29 days after the treatment. GCS wasassessed respectively on the admission and 14 d after the treatment, and the prognoses were assessed by GOS 3 months after thetreatment in all the patients.ResultsThe plasma levels of 8-iso-PGF2 αwere significantly higher 1 day after the treatment than thosebefore the treatment in both the（P〈0.05）, and they were significantly lower 2, 6, 13 and 29 days after the treatment than those before thetreatment in both the groups（P〈0.05）. The plasma levels of 8-iso-PGF2αwere significantly lower in the treatment group than those in thecontrol group 6, 13 and 29 days after the treatment（P0.01）. The scores of GCS were significantly higher 13 days after the treatment thanthose before the treatment in both the group（P0.01）. The scores of GCS were significantly higher in the treatment group than those inthe control group 13 days after the treatment（P0.01）. The scores of GOS were significantly higher in the treatment group than those inthe control group 3 months after the treatment（P0.01）.ConclusionThe plasma level of 8-iso-PGF2αmay be reduced and the prognosismay be improved by the venous injection of endaravone in the patients with severe craniocerebral trauma.

关 键 词：颅脑损伤 依达拉奉 8-表氧前列腺素F2α 预后 

分 类 号：R651.15[医药卫生—外科学]