绿茶提取物改善代谢综合征患者脂质代谢的meta分析  

Green tea extract improves the lipid metabolism in patients with metabolic syndrome： a meta-analysis

作　　者：李秀敏[1] 吴黄辉[2] 肖远[1] 王晓明[1] 

机构地区：[1]第四军医大学西京医院老年病科,西安710032 [2]南京军区福州总医院麻醉科

出　　处：《中华内分泌代谢杂志》2015年第3期224-229,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81270169）

摘　　要：目的系统评价绿茶提取物改善代谢综合征患者脂质代谢的疗效和安全性。方法计算机检索中英文文献，收集绿茶提取物与代谢综合征患者脂质代谢相关的随机对照试验，采用RevMan5．2软件进行meta分析。结果纳入9篇随机对照研究文献，共566例代谢综合征患者。Meta分析结果显示，与安慰剂组相比，在治疗终点时绿茶提取物有效降低代谢综合征患者低密度脂蛋白胆固醇（LDL—C）水平[SMD=-0．33，95％CI（-0．56，-0．09），P=0．007]，差异有统计学意义，高密度脂蛋白胆固醇[SMD=0．19，95％CU（-0．04，0．43），P=0．10]、总胆固醇[SMD=-0．13，95％CI（-0．39，0．13），P=0．33]及甘油三酯[SMD=-0．07，95％CI（-0．46，0．33），P=0．74]水平2组差异无统计学意义。绿茶提取物组和安慰剂组总体不良反应发生率差异无统计学意义[OR=0．97，95％CI（0．54，1．76），P=0．93]。结论绿茶提取物可有效降低代谢综合征患者LDL-C水平，且不良反应少。Objective To systematically evaluate the efficacy and safety of green tea extract （GTE） in improving lipid metabolism in patients with metabolic syndrome （MS）. Methods All relevant published articles in Chinese and English literature database were searched to collect the randomized controlled trials comparing the efficiency and safety of GTE in patients with MS. The meta-analysis was performed using RevMan 5.2 software. Results Nine studies involving 566 patients were included. The results of meta-analysis showed that： GTE significantly reduced the level of low-density lipoprotein cholesterol （LDL-C） （SMD =-0.33, 95% CI -0.56 --0.09, P = 0. 007 ） compared with placebo at the treatment endpoint. There were no statistical significance in high- density lipoprotein cholesterol （ SMD=0.19, 95% CI-0.04- 0.43, P = 0.10 ）, total cholesterol （ SMD = -0.13, 95% CI-0.39 - 0.13, P = 0.33 ）, and triglyceride （ SMD = -0.07, 95% CI -0.46 - 0.33, P = 0.74） levels between two groups. There was no significant difference in the overall rate of adverse events between two groups （ OR = 0.97,95 % CI 0. 54 - 1.76, P = 0.93 ）. Conclusion GTE significantly reduces the level of LDL-C in patients with MS, and the adverse events were rare and mild.

关 键 词：绿茶提取物 代谢综合征 脂质代谢 META分析 随机对照研究 

分 类 号：R589[医药卫生—内分泌]