有机催化不对称Henry反应研究进展  

Progress in Asymmetric Organocatalytic Henry Reactions

作　　者：杨翠凤[1] 林双政[1] 王月梅[1] 宁斌科[1] 

机构地区：[1]西安近代化学研究所,陕西西安710065

出　　处：《化学试剂》2015年第4期319-324,共6页Chemical Reagents

摘　　要：Henry是一个重要的人名反应,在有机合成中具有广泛的应用。分别概述了醛、酮化合物和硝基烷烃在有机小分子催化作用下的不对称Henry反应,以及有机催化的不对称串联Michael/Henry反应。对于胍、硫脲、胺、相转移催化剂及奎宁衍生物(类似物)等不同类型有机小分子催化不对称Henry反应作了概述。并对有机催化不对称Henry反应的研究作了相应的展望。Henry reaction is an important name reaction,which is widely employed as a powerful C--C bond-forming tool in organ- ic syntheses. In this work,the asymmetric organocatalytic Henry reactions of aldehydes with nitroalkanes and the asymmetric or- ganoeatalytic Henry reactions of ketones with nitroalkanes were investigated, respectively. The enantioseleetive organocatalytic domino Michael/Henry reactions were also reviewed. The organoeatalysts engaged in the reactions could be guanidines,thioureas, amines, phase-transfer catalysts, quinine derivatives or analogues and so on. In addition, further research advances were expected.

关 键 词：Henry反应 有机催化 不对称催化 立体选择性反应 串联反应 

分 类 号：O621.3[理学—有机化学]