血必净联合头孢硫脒治疗急性盆腔腹膜炎47例临床研究  

Clinical Study on the Efficacy of Xuebijing Injection Combined with Cefathiamidine in Treating 47 Cases of Acute Pelvic Peritonitis

作　　者：孙海艳 赵春生[2] 孙常华 

机构地区：[1]河北省承德市中医院中医科,河北承德067000 [2]承德医学院附属医院急诊科,河北承德067000

出　　处：《中国药业》2015年第7期12-14,共3页China Pharmaceuticals

摘　　要：目的观察血必净注射液联合头孢硫脒注射液治疗急性盆腔腹膜炎的临床效果。方法选取94例急性盆腔腹膜炎患者,随机分为研究组和对照组,各47例。研究组应用血必净(50mL/次,2次/日)联合头孢硫脒(1.5g/次,1次/日)治疗,对照组只用头孢硫脒(1.5g/次,1次/日)治疗,两组疗程均为14d。1个月后评价中医症状改善情况,判定临床疗效与炎性指标变化。结果治疗后,研究组与对照组在恶寒[(1.18±0.49)分比(1.84±0.73分)]、发热[(0.79±0.32)分比(1.32±0.57分)]、咳嗽[(1.35±0.46)分比(1.87±0.41)分],月经[(1.77±0.55)分比(2.08±0.45)分],带下[(1.75±0.54)分比(2.01±0.62)分]等中医症状积分比较,差异均具有统计学意义(P<0.05);研究组治愈率为48.94%显著高于对照组的23.40%(P<0.05),两组临床总有效率(93.62%比87.23%)比较,差异无统计学意义(P>0.05);两组治疗后白细胞总数[(7.37±2.31)×109/L比(9.88±2.43)×109]、C反应蛋白(CRP)[(7.29±2.20)mg/L比(9.38±2.15)mg/L]、降钙素原(PCT)[(14.35±3.44)ng/L比(16.82±4.58)ng/L]、白细胞介素6(IL-6)[(137.62±25.21)ng/L比(152.72±28.61)ng/L]等炎症指标比较,差异显著(P<0.05);两组患者在治疗期及随访期间均未见明显不良反应,安全性评价为1级。结论急性盆腔腹膜炎患者应用血必净联合头孢硫脒治疗,效果优于单用头孢硫脒,尤其在中医症状改善方面表现出显著优势,且临床安全性较高。Objective To explore the clinical efficacy of Xuebijing Injection combined with Cefathiamidine Injection in the treatment of acute pelvic peritonitis.Methods 94 selected patients with acute pelvic peritonitis were randomly divided into the study group and the control group,47 cases each.The study group was given the regimen of Xuebijing Injection（50mL,twice daily） combined with Cefathi-amidine Injection（1.5g,once daily）,while the control group was only given cefathiamidine（1.5 g,once daily）.The two groups were treat-ed for 14d. The improvement of Chinese medicine symptoms after 1 month was evaluated.The clinical effects and the changes of the inflammatory indexes were also evaluated.Results The Chinese medicine symptom integrals after treatment had statistical differences in chills（1.18±0.49 vs.1.84±0.73）,fever（0.79±0.32 vs.1.32±0.57）,cough（1.35±0.46 vs.1.87±0.41）,menstruation（1.77±0.55 vs.2.08±0.45） and leucorrhea（1.75±0.54 vs.2.01±0.62） between the two groups（P〈0.05）;the cure rate of the study group was significantly higher than that of the control group（48.94% vs.23.4%,P〈0.05）,but the clinical total effective rates had no statistical difference between the two groups（93.62% vs.87.23%,P〈0.05）; the inflammatory indexes of total white blood cells（WBC） count [（7.37±2.31）×10^9L vs.（9.88±2.43）×10^9,C-reactive protein（CRP） [（7.29±2.20）mg/L vs.（9.38±2.15）mg/L],procalcitonin（PCT） [（14.35±3.44）ng/L vs.（16.82 ±4.58）ng/L] and interleukin-6（IL-6） [（137.62 ±25.21）ng/L vs.（152.72 ±28.61）ng/L] had statistical differences between the two groups（P〈0.05）;there were no obvious adverse reactions during the treatment period and following-up in the two groups,the safety evaluation was the grade 1.Conclusion Xuebijing Injection combined with Cefathiamidine Injection has better effect for treating acute pelvic peritonitis than single cefathiamidine,shows the significant advan-tage especially in the aspect of the

关 键 词：盆腔腹膜炎 血必净注射液 头孢硫脒 中医症状积分 疗效 

分 类 号：R285.6[医药卫生—中药学] R286[医药卫生—中医学]