盐酸非索非那定片联合丙酸氟替卡松治疗变应性鼻炎的疗效及对血清细胞因子的影响  

Effect of Combination Medication Scheme of Fexofenadine Hydrochloride Tablets and Fluticasone Propionate on Clinical Symptoms and Serum IFN-γ and IL-4Levels in Allergic Rhinitis

作　　者：黄春蓓[1] 龚宇[1] 

机构地区：[1]重庆市第九人民医院耳鼻喉科,重庆400700

出　　处：《中国药业》2015年第7期32-33,共2页China Pharmaceuticals

摘　　要：目的探讨盐酸非索非那定片联合丙酸氟替卡松对变应性鼻炎的疗效及血清干扰素-γ(IFN-γ)及白细胞介素(IL-4)的影响。方法将86例变应性鼻炎患者随机分成观察组和对照组,各43例。对照组给予丙酸氟替卡松鼻喷剂喷鼻治疗,观察组加用口服盐酸非索非那定片治疗,观察两组患者临床症状积分、临床疗效、治疗前后血清IFN-γ及IL-4的变化,以及不良反应。结果观察组临床症状评分为(3.84±1.65)分,明显低于对照组(P<0.01);观察组治疗总有效率为90.70%,明显高于对照组的72.09%(P<0.05);观察组治疗后IFN-γ为(56.14±10.34)ng/m L,明显低于对照组的(78.32±12.62)ng/m L(P<0.01),而IL-4为(68.61±10.26)ng/m L,明显高于对照组的(57.40±11.83)ng/m L(P<0.01);两组不良反应比较无统计学差异(P>0.05)。结论盐酸非索非那定片、丙酸氟替卡松联合用药方案治疗变应性鼻炎,能有效改善临床症状,改善免疫失衡状态,提高治疗效果。Objective To study the effect of Fexofenadine Hydrochloride Tablets combined with fluticasone propionate on the symptoms and serum levels of IFN-γ and IL-4 in allergic rhinitis.Methods 86 patients with allergic rhinitis were randomly divided into the observation group and the control group,43 cases in each group.The control group was given Fluticasone Propionate Nasal Spray for conducting the nasal spray therapy,while the observation group was added with oral Fexofenadine Hydrochloride Tablets.The clinical symptoms integral,clinical efficacy,change of serum IFN-γ and IL-4 levels before and after treatment,and adverse reactions were ob-served and compared between the two groups.Results The clinical symptom scores in the observation group were 3.84 ±1.65,which were significantly lower than those in the control group;the effective rate in the observation group was 90.70%,which was significantly higher than 72.09% in the control group;serum IFN-γ level was（56.14±10.34）ng/m L,which was significantly lower than（78.32±12.62）ng/m L that in the control group（P〈0.05）,serum IL-4 level was（68.61±10.26）ng/m L,which was significantly higher than（57.40±11.83）ng/m L in the control group（P〈0.01）;there were no statistical difference in the adverse reactions be-tween the two groups（P〉 0.05）.Conclusion The combination medication scheme of Fexofenadine Hydrochloride Tablets and fluticas-one propionate for treating allergic rhinitis can effectively improve the clinical symptoms,improve immune imbalance status and increase the treatment effect.

关 键 词：盐酸非索非那定片 丙酸氟替卡松 变应性鼻炎 临床疗效 免疫水平 

分 类 号：R969.4[医药卫生—药理学] R976[医药卫生—药学]