线状IgA大疱性皮肤病1例报道并文献复习  

One Case Report of Linear Ig A Bullous Dermatosis and Literature Review

作　　者：乔丽[1] 杨志勇[1] 田蓉[1] 

机构地区：[1]中国人民解放军空军总医院皮肤科,北京100142

出　　处：《中国药业》2015年第7期81-82,共2页China Pharmaceuticals

摘　　要：目的探讨线状IgA大疱性皮肤病(LABD)的病因、诊断和鉴别诊断、治疗及预后,以提高对该病的认识。方法对1例LABD患者的临床资料、组织病理、免疫荧光进行分析,并对相关文献进行分析。结果患者表现在红斑基础上的水疱,或外观正常皮肤上出现的水疱,病理组织活检和免疫荧光确诊为LABD。结论 LABD是一种少见的自身免疫性表皮下大疱病,确切的发病机制还不清楚。常见的靶抗原有LAD97,LAD-1,BP180,BP230和LAD285等,其中BP180抗原可能在发病中起作用。特征性的基底膜带线状IgA抗体沉积为确诊本病的主要依据。氨苯砜是治疗LABD的首选药物。Objective To investigate the etiology,diagnosis and differential diagnosis,treatment and prognosis of linear IgA bullous der-matosis（LABD） for improving the cognition on this disease.Methods The clinical,histopathological and immunofluorescence data in one case of LABD were analyzed and the relevant literature was analyzed.Results The patient with LABD showed blisters on the basis of erythema or blisters appeared on the skin with normal appearance.The histopathological and immunofluorescence biopsy diagnosed as LABD.Conclusion LABD is a rare autoimmune subepidermal bullous disease.The common target antigens are LAD97,LAD-1,BP180,BP230,LAD285,etc.,in which BP180 antigen may play a role in the pathogenesis.The characteristic basement membrane linear IgA an-tibody deposition is the main basis for diagnosing LABD.Dapsone is the drug of first choice for treating LABD.

关 键 词：线状IgA大疱性皮肤病 IgA抗体沉积 氨苯砜 

分 类 号：R758.59[医药卫生—皮肤病学与性病学]