声辐射脉冲成像技术定量诊断弥漫性脂肪肝及评价水飞蓟宾磷脂复合物疗效的价值  

Analysis on Clinical Application Value of ARFI Technology and Silybin Phospholipid Complex in Quantitatively Diagnosing and Treating Diffuse Fatty Liver

作　　者：张志志 王娟 焦俊杰 李淑英 

机构地区：[1]河北省秦皇岛市港口医院,河北秦皇岛066000

出　　处：《中国药业》2015年第7期97-99,共3页China Pharmaceuticals

基　　金：2014年河北省秦皇岛市市级科技计划(第一批);项目编号:201401A086

摘　　要：目的探讨声辐射脉冲成像技术(ARFI)在定量诊断弥漫性脂肪肝和评价水飞蓟宾磷脂复合物疗效的临床应用价值。方法选取2012年1月至2014年1月医院就诊的弥漫性脂肪肝患者50例,分为轻度、中度和重度3组。同时选取同期体检的50例健康人作为对照组。对比四组的声触诊组织定量(VTQ)值、肝功能和血脂水平,分析VTQ值和肝功能、血脂水平之间的相关性。采用水飞蓟宾磷脂复合物治疗4周后,对比所有患者治疗前后的VTQ、肝功能和血脂水平。结果随着脂肪肝程度加重,VTQ值逐渐升高(P<0.05),丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)、三酰甘油(TG)和总胆固醇(TC)水平也逐渐升高(P<0.05)。采用Spearman相关分析,VTQ值和ALT(r=0.405,P=0.042<0.05)、AST(r=0.519,P=0.044<0.05)、TG(r=0.490,P=0.038<0.05)、TC(r=0.523,P=0.037<0.05)之间均存在正相关。3组患者治疗4周后的VTQ,ALT,AST,TG和TC水平均显著低于治疗前(P<0.05)。结论 ARFI可用于量化诊断弥漫性脂肪肝和评价水飞蓟宾磷脂复合物的疗效。Objective To investigate the clinical application value of acoustic radiation force impulse techniques（ARFI） in quantitative diagnosis of diffuse fatty liver and to evaluate the effect of silybin phospholipid complex therapy.Methods 50 patients with diffuse fat-ty liver in our hospital from January 2012 to January 2014 were selected and divided into mild,moderate and severe groups.Meanwhile 50 people of healthy physical examination over the same period were selected as the control group.The virtual touch tissue quantication（VTQ） value,liver function and blood lipid levels were compared among the patients in the four groups.The correlation between the VTQ value with the liver function and lipid levels was analyzed.After 4-week silybin phospholipid complex treatment,the VTQ values,liver function and blood lipid levels were compared between before and after treatment in all the patients.Results The VTQ value was increased with the gradual increase of fatty liver severity（P〈0.05）.The ALT,AST,TG and TC levels were gradually increased with the increase of fatty liver degree（P〈0.05）.The Spearman correlation analysis showed that the VTQ value was positively correlated with ALT（r=0.405,P=0.0420.05）,AST（r=0.519,P=0.0440.05）,TG（r=0.490,P=0.0380.05） and TC（r=0.523,P=0.0370.05）.The VTQ,ALT,AST,TG and TC levels after 4-week treatment were significantly lower than those before treatment（P 0.05）.Conclusion The ARFI technique can be used for quantifying diffuse fatty liver and evaluating the curative effect of sily-bin phospholipid complex.

关 键 词：声辐射脉冲成像技术 定量诊断 弥漫性脂肪肝 水飞蓟宾磷脂复合物 

分 类 号：R969.4[医药卫生—药理学] R445.1[医药卫生—药学]