靶控输注丙泊酚和不同剂量的舒芬太尼用于宫颈癌根治手术的研究  

Clinical research of radical hysterectomy with target-controlled infusion of Propofol and different doses of Sufentanil

作　　者：徐林[1] 

机构地区：[1]江西省妇幼保健院,南昌330006

出　　处：《江西医药》2015年第3期198-201,共4页Jiangxi Medical Journal

基　　金：江西省卫生厅科技项目(20131127)

摘　　要：目的观察不同浓度舒芬太尼与丙泊酚复合靶控输注应用于宫颈癌根治术的临床效果。方法选择宫颈癌根治术患者60例,随机分为3组。3组舒芬太尼效应室靶浓度分别为0.2ng/ml(S1),0.25ng/ml(S2),0.3ng/ml(S3),复合丙泊酚靶控4-6μg/ml,观察记录3组血流动力学、苏醒时间及术后疼痛情况。结果 0.3ng/ml舒芬太尼各时点平均动脉压和心率均低于0.2ng/ml组和0.25ng/ml组(P<0.05),并且本组术后疼痛评分亦低于另外两组(P<0.05),3组苏醒时间无统计学差异。结论宫颈癌根治术中,丙泊酚静脉麻醉复合靶控输注0.3ng/ml的舒芬太尼比0.2ng/ml和0.25ng/ml组能更有效抑制气管插管和手术的伤害性刺激,并能提供良好的术后镇痛条件。Objective To observe the effects of different doses Sufentanil combined with Propofol in target-controlled infusion（TCI） on radical hysterectomy. Methods A total of 60 patients with uterine cervix cancer were recruited. They were randomly divided into three groups（each n=20） according to different target concentrations of sufentanil. These target concentrations were 0.2ng/ml（group S1）,0.25ng/ml（group S2） and 0.3ng/ml（group S3） respectively combined with propofol 4-6ug/ml. Heart rat（HR）,Mean arterial pressure（MAP） and Bispectral Index（BIS） were monitored continuously. The pain intensity was evaluated by vision assessment score（VAS）. The hemodynamic parameters,revive times and VAS scores were recorded. Results Compared with other two groups,of all time points which we recorded after anesthesia,HR of group S3 was slower（P0.05）,and MAP of this group was lower（P0.05）. VAS score in group S3 was less than the other two groups at 30 min after extubation（P0.05）. There were no significant different in revive times among the three groups. Conclusion Sufentanil TCI at 0.3ng/ml compounded propofol is more effective in inhibiting hemodynamic response to tracheal intubation and nociceptive stimulus of operation than that of 0.2ng/ml an 0.25ng/ml. And it has the same result in postoperative pain control.

关 键 词：舒芬太尼 丙泊酚 宫颈癌根治术 

分 类 号：R614[医药卫生—麻醉学]