104例系统性红斑狼疮患者血清指标的变化及C1q抗体的表达  

Changes of serum markers and expression of C1q antibody in 104 cases of systemic lupus erythematosus patients

作　　者：安和兵[1] 董玉飞[1] 杨健宝 陈乐[2] 庞卫华[1] 常永峰[1] 杨敬芳[1] 

机构地区：[1]河北北方学院附属第二医院检验科,河北张家口075100 [2]河北北方学院附属第二医院五官科,河北张家口075100

出　　处：《检验医学与临床》2015年第7期923-925,共3页Laboratory Medicine and Clinic

摘　　要：目的检测系统性红斑狼疮(SLE)患者血清指标及C1q抗体(Anti-C1q)的变化,并探讨其临床意义。方法选取104例SLE患者(SLE组)及100例体检健康者(健康对照组)作为研究对象,检测其血清中Anti-C1q、双链DNA(dsDNA)抗体、其他相关自身抗体及生化指标,并对结果进行分析。结果与健康对照组相比,SLE组的三酰甘油(TG)水平升高[(3.89±0.65)mmol/L vs.(1.12±0.48)mmol/L,P<0.05],高密度脂蛋白(HDL)水平降低[(0.8±0.2)mmol/L vs.(1.2±0.3)mmol/L,P<0.05],超敏C反应蛋白(hs-CRP)水平升高[(5.5±1.4)mg/L vs.(0.9±0.6)mg/L,P<0.05],补体C3水平降低[(87.6±14.7)mg/L vs.(128.2±20.3)mg/L,P<0.05],补体C4水平降低[(16.2±4.8)mg/L vs.(29.1±7.4)mg/L,P<0.05]。SLE组Anti-C1q水平较健康对照组明显升高[(44±20)U/mL vs.(6.5±1.8)U/mL,P<0.05],其中活动期SLE患者Anti-C1q水平明显高于非活动期患者(P<0.05),狼疮性肾炎(LN)患者Anti-C1q水平明显高于非LN患者(P<0.05),dsDNA抗体阳性者Anti-C1q水平明显高于dsDNA抗体阴性者(P<0.05)。结论 SLE患者外周血中各种生化指标和自身抗体的异常为患者疾病诊断提供了一定的理论依据,其中Anti-C1q的异常表达更有助于对活动期SLE和LN的诊断。Objective To detect the changes of serum markers and C1 q antibody（Anti-C1q）in patients with systemic lupus erythematosus（SLE）,and to discuss the clinical significance.Methods 104 cases of SLE patients（SLE group）and 100 cases of healthy people（normal control group）were selected as research objects.The serum levels of Anti-C1 q,double-stranded DNA antibodies（dsDNA antibodies）,some other related autoantibodies and biochemical markers of the two groups were detected,and the results were analyzed.Results Comparing with normal control group,TG level of SLE group was increased[（3.89±0.65）mmol/L vs.（1.12±0.48）mmol/L,P〈0.05],HDL level was depressed[（0.8±0.2）mmol/L vs.（1.2±0.3）mmol/L,P〈0.05],hs-CRP level was increased[（5.5±1.4）mg/L vs.（0.9±0.6）mg/L,P〈0.05],C3 level was depressed [（87.6±14.7）mg/L vs.（128.2±20.3）mg/L,P〈0.05],and C4 level was depressed[（16.2±4.8）mg/L vs.（29.1±7.4）mg/L,P〈0.05].The serum Anti-C1 q level of SLE group was significantly higher than that of normal control group [（44±20）U/mL vs.（6.5±1.8）U/mL,P〈0.05].In SLE group,the serum Anti-C1 q levels of patients with active SLE was significantly higher than that of patients with non-active SLE（P〈0.05）,which of lupus nephritis（LN）patients was significantly higher than that of non-lupus nephritis patients（P〈0.05）,and which of patients with positive dsDNA antibodies was significantly higher than that of patients with negative dsDNA antibodies（P〈0.05）.Conclusion The abnormal expression of Anti-C1 q would help to diagnose active SLE and LN.

关 键 词：系统性红斑狼疮 狼疮性肾炎 C1Q抗体 抗核抗体 dsDNA抗体 

分 类 号：R758.62[医药卫生—皮肤病学与性病学]