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作 者:邓永洪[1] 张荣贵[1] 刘红霞[1] 刘仁红[1] 李小玲[1] 肖毅[1]
机构地区:[1]广州医科大学附属深圳沙井医院儿科,广东深圳518104
出 处:《河北医学》2015年第6期920-922,共3页Hebei Medicine
基 金:2012年度广东省深圳市宝安区科技计划项目;(编号:2012137)
摘 要:目的:探讨难治性肺炎支原体肺炎(RMPP)患儿免疫功能变化及匹多莫德的干预作用。方法:50例RMPP患儿及50例健康儿童纳入本研究,将RMPP患儿随机分为A、B两组,A组患儿予常规阿奇霉素联合匹多莫德治疗,B组患儿常规阿奇霉素治疗,检测对照组儿童及RMPP患儿治疗前后外周血T细胞亚群的变化,并比较A、B两组患儿的临床疗效。结果:RMPP患儿与对照组比较,血清CD3+、CD4+、CD4+/CD8+明显降低,差异有统计学意义(P<0.05);治疗后,A、B两组RMPP患儿血清CD3+、CD4+及CD4+/CD8+比值较治疗前明显升高,且A组明显高于B组水平,差异均有统计学意义(P<0.05);随访期间A组患儿平均病情反复次数、持续时间及使用抗生素时间均明显少于B组,差异均有统计学意义(P<0.05)。结论:难治性肺炎支原体肺炎患儿存在免疫功能紊乱,匹多莫德可通过调节免疫平衡,增强患儿免疫力,进而提高临床疗效。Objective:To investigate the change of immune function and effect of immune intervention in children with refractory mycoplasma pneumoniae pneumonia ( RMPP ) .Method:50 children with RMPP and 50 cases of healthy children were studied ,and RMPP children were randomly divided into groups A , B, group A were treated with conventional azithromycin , group B were combined with pidotimod , the peripheral blood T cell subsets were etected in control and RMPP children (before and after treatment),and clinical ef-ficacy were compared. Result: The level of serum CD3+ ,CD4+ and CD4+/CD8+ in RMPP children was sig- nificantly lower than the control group( P〈0.05 ) ; after treatment, the level of serum CD3+ , CD4+ and CD4+/ CD8+ in group A and B was significantly higher than before treatment, and those in group A was significantly higher than group B, the differences were statistically significant (P〈0.05) ; the average number of iterations illness, duration and time of use of antibiotics in group A were significantly less than group B (P〈0.05). Conclusion: There's immune dysfunction in children with RMPP, pidotimod can regulate the immune bal- ance, strengthen the immune system in children, and to improve clinical efficacy.
关 键 词:难治性肺炎支原体肺炎 T淋巴细胞亚群 匹多莫德
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