干扰素释放试验在AIDS合并结核感染患者中的诊断价值  

Diagnostic value of interferon-γrelease test in acquired immune deficiency syndrome complicating tuberculosis infection

作　　者：赵磊[1] 薛剑[1] 杜君晓[1] 王瑜玲[1] 王伟[1] 

机构地区：[1]石家庄市第五医院结核科/石家庄市结核病防治研究所,河北石家庄050000

出　　处：《重庆医学》2015年第11期1484-1486,共3页Chongqing medicine

基　　金：石家庄科学技术研究与发展计划基金项目(121461833);河北省科技技术研究与发展计划项目(12277746)

摘　　要：目的评价4种诊断方法对人获得性免疫缺陷综合征(AIDS)合并结核病(TB)患者的诊断价值。方法将52例人类免疫缺陷病毒(HIV)感染合并TB患者作为观察组,100例未感染HIV的TB患者为对照组,对两组患者进行结核菌素(PPD)试验、痰结核菌培养、结核抗体和γ干扰素释放试验(IGRA)进行诊断。结果对照组患者PPD试验、痰结核菌培养和结核抗体阳性率明显高于观察组患者,差异有统计学意义(P<0.01);而IGRA阳性率两组比较,差异无统计学意义(P>0.05);观察组IGRA阳性明显高于PPD试验、痰结核菌培养和结核抗体阳性率,均差异有统计学意义(P<0.01)。抗逆转录病毒治疗观察组患者IGRA阴性发生率明显高于阳性率,差异有统计学意义(P<0.05)。结论 IGRA是诊断HIV感染合并TB的敏感方法,而抗逆转录病毒治疗可能对结果有一定的影响。Objective To evaluate the value of the four kinds of diagnostic method in acquired immune deficiency syndrome （AIDS） infection complicating tuberculosis （TB） .Methods 52 cases of human immunodeficiency virus （HIV） infection complica‐ting TB were taken as the observation group and 100 cases of TB without complicating HIV infection were taken as the control group .The two groups were performed the PPD test ,sputum Mycobacterium tuberculosis culture ,tuberculosis antibody and inter‐feron gamma release assay（IGRA） for conducting the diagnosis .Results The positive rate of the PPD test ,sputum Mycobacterium tuberculosis culture and tuberculosis antibody in the control group were significantly higher than those in the observation group ,the differences were statistically significant （P〈0 .01）;the positive rate of the IGRA in the observation group was obviously higher than that of the PPD test ,sputum Mycobacterium tuberculosis culture and tuberculosis antibody ,the differences had statistical sig‐nificance （P〈0 .01） .The negative occurrence rate of the IGRA in the observation group treated by the antiretroviral therapy was obviously higher than the positive rate ,the difference was statistically significant （P〈0 .05） .Conclusion The IGRA may be a sen‐sitive method for diagnosing HIV infection complicating TB and the antiretroviral therapy may have a certain impact on the results .

关 键 词：获得性免疫缺陷综合征 HIV 结核 Γ干扰素释放试验 

分 类 号：R521[医药卫生—内科学]