扩张型心肌病患者血清促血管生成素-2水平的改变及其临床意义  

Changes in serum angiopoietin-2 level and their clinical significance in patients with dilated cardiomyopathy

作　　者：齐彬[1] 刘司娜 韦晓敏[1] 桂春[1] 

机构地区：[1]广西医科大学第一附属医院心血管内科,南宁市530021

出　　处：《广西医学》2015年第2期154-156,共3页Guangxi Medical Journal

基　　金：国家自然科学基金资助项目(81160021);广西自然科学基金资助项目(GXNSFA018223)

摘　　要：目的探讨扩张型心肌病合并心力衰竭患者血清促血管生成素-2(Ang-2)水平的改变及其临床意义。方法采用酶联免疫吸附试验检测扩张型心肌病合并心力衰竭患者33例(心肌病组)、健康者33例(对照组)血清中Ang-2及脑利钠肽(BNP)水平,分析其水平与心脏超声指标的相关性。结果心肌病组血清Ang-2、BNP水平均明显高于对照组(P<0.05);心肌病组患者血清Ang-2水平与左室射血分数呈负相关关系(P<0.05),与左室舒张末期及收缩末期内径呈正相关关系(P<0.05)。结论扩张型心肌病合并心力衰竭患者血清Ang-2水平明显增高,Ang-2有望成为一个预测及评价扩张型心肌病及其严重程度的新指标。Objective To investigate the changes in the level of serum angiopoietin-2 （ Ang-2 ） and their clinical significance in dilated cardiomyopathy （ DCM） patients with heart failure .Methods The levels of serum Ang-2 and brain natriuretic peptide （ BNP） were detected by enzyme-linked immunosorbent assay in 33 DCM patients with heart failure （ DCM group ） and 33 healthy controls （ control group） .The correlation of the levels with cardiac ultrasonic indexes was analyzed .Results The levels of serum Ang-2 and BNP in the DCM group were significantly higher than those in the control group （P〈0.05）.The level of serum Ang-2 negatively correlated with left ventricular ejection fraction（P〈0.05）,but positively correlated with left ventricular end-diastolic diameter and left ventricular end-systolic diameter in the DCM group（P〈0.05）.Conclusion The level of serum Ang-2 increases significantly in DCM patients with heart failure . Ang-2 is expected to be a prediction which is used to predict and evaluate the severity of DCM .

关 键 词：扩张型心肌病 促血管生成素-2 心力衰竭 脑尿钠肽 

分 类 号：R542.2[医药卫生—心血管疾病]