五子承气汤对痛风性肾病大鼠肾功能的影响  

Effects of Wuzichengqitang on renal function in gouty nephropathy rats

作　　者：周文生[1] 牟科媛[1] 袁兴卫[1] 蒙莉[1] 李丽[2] 

机构地区：[1]广西玉林市卫生学校附属医院,玉林市537000 [2]广西中医药大学药学院,南宁市530001

出　　处：《广西医学》2015年第2期207-209,共3页Guangxi Medical Journal

基　　金：广西自然科学基金项目(2011GXNSFA018210)

摘　　要：目的探讨五子承气汤对痛风性肾病(GN)大鼠肾功能的影响。方法将雄性SD大鼠60只按随机数字表法分为6组,即:正常对照组、模型组、五子承气汤高、中、低剂量组(104 g、52 g、26 g生药/kg)、阳性对照组(苯溴马隆10 mg/kg),采用腺嘌呤和氧嗪酸钾盐制备GN大鼠模型。造模4周后,检测各组大鼠肾指数、血肌酐(Scr)、尿素氮(BUN)。结果五子承气汤高、中、低剂量组均能显著降低GN大鼠的肾指数(P<0.05),呈高剂量组<中剂量组<低剂量组(P<0.01)。五子承气汤组中、高剂量组均能降低GN大鼠血Scr、BUN含量(P<0.05),高剂量组降低作用更明显(P<0.01)。结论五子承气汤有改善GN大鼠肾功能的作用。Objective To explore the effects of Wuzichengqitang on renal function in gouty nephropathy （ GN） rats.Methods Sixty male SD rats were randomly divided into six groups ,normal control group ,model group ,high-,middle-and low-dose Wuzichengqitang groups（crude drug,104 g,52 g,26 g/kg）,and positive control group （ benzbromarone,10 mg/kg）.The GN rat model was induced by adenine and potassium oxonate.Four weeks after modeling,the renal index,serum creatinine（Scr） and blood urea nitrogen（BUN） of rats were detected in each group.Results The renal index of GN rats decreased significantly in the high-,middle-and low-dose Wuzichengqitang groups（P〈0.05）,which was the lowest in the high-dose Wuzichengqitang group while the highest in the low-dose Wuzichengqitang group （P〈0.01）.The contents of Scr and BUN of GN rats decreased in the middle-and high-dose Wuzichengqitang groups （P〈0.05）,and the decrease was more significant in the high-dose Wuzichengqitang group （ P〈0.01 ） .Conclusion Wuzichengqitang plays a role in the improvement of renal function in GN rats .

关 键 词：痛风性肾病 五子承气汤 血清肌酐 尿素氮 肾功能 大鼠 

分 类 号：R692[医药卫生—泌尿科学] R589.7[医药卫生—外科学]