老年2型糖尿病患者胰岛素样生长因子1及胱抑素C与糖尿病肾病的关系  

Relation of insulin-like growth factor-1 and cystatin C levels with diabetic nephropathy in elderly patients with type 2 diabetes mellitus

作　　者：陈海燕 宝轶[1] 叶菲[1] 石勇铨[1] 刘志民[1] 邹俊杰[1] 

机构地区：[1]第二军医大学附属长征医院内分泌科,上海200003

出　　处：《中华老年心脑血管病杂志》2015年第4期342-345,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：上海市自然科学基金(13ZR1414700);第二军医大学青年启动基金(2011QN16)

摘　　要：目的研究血清胰岛素样生长因子1(IGF-1)水平及血清胱抑素C在2型糖尿病(T2DM)肾病患者的变化及临床意义。方法根据尿白蛋白排泄率水平,将其分为单纯T2DM组63例,早期糖尿病性肾病(DN)组60例,临床期DN组65例,另选择60例健康体检者作为正常对照组(对照组)。采用酶联免疫吸附法检测各组血清IGF-1及血清胱抑素C水平,电化学发光法检测尿白蛋白,再计算尿白蛋白排泄率。结果与对照组比较,单纯T2DM组、早期DN组及临床期DN组IGF-1水平[(175.35±12.43)μg/L、(221.19±25.06)μg/L、(248.77±35.88)μg/L vs(136.86±28.32)μg/L]明显升高,差异有统计学意义(P<0.05);早期DN组、临床期DN组IGF-1水平较T2DM组升高,差异有统计学意义(P<0.05);早期DN组、临床期DN组血清胱抑素C水平较对照组、单纯T2DM组明显升高,差异有统计学意义(P<0.05)。多元线性回归分析显示,尿白蛋白排泄率和胱抑素C是IGF-1的影响因素(P<0.01)。结论 IGF-1及血清胱抑素C与T2DM肾病的发生发展有显著相关性,是临床较为敏感的指标,具有早期提示意义。Objective To study the relation of serum insulin-like growth factor-1（IGF-1）and cystatin C（Cyst C）levels with diabetic nephropathy（DN）in patients with type 2diabetes mellitus（T2DM）.Methods One hundred and eighty-eight T2 DM patients were divided into simple T2 DM group（n=63）,early DN group（n=60）and clinical stage DN group（n=65）,and 60 healthy subjects who underwent physical examination served as a control group.Their serum IGF-1and Cyst C levels were measured by ELISA.The urinary albumin was detected by electrochemiluminescence immunoassay and its excretion rate was calculated.Results The serum IGF-1level was significantly higher in simple T2 DM group,early DN group and clinical stage DN group than in control group（P〈0.05）and in early DN group and clinical stage DN group than in simple T2 DM group（P〈0.05）.The serum Cyst C level was significantly higher in simple T2 DM group,early DN group and clinical stage DN group than in control group（P〈0.05）.Conclusion The serum IGF-1and Cyst C levels are closely related with DN in T2 DM patients and are thus a sensitive indicator of DN.

关 键 词：糖尿病 2型 糖尿病肾病 胰岛素样生长因子Ⅰ 肾小球滤过率 酶联免疫吸附测定 

分 类 号：R587.2[医药卫生—内分泌]