襄阳地区不孕不育者感染支原体衣原体情况分析初报——湖北省教育厅科技计划项目《襄阳市感染、自身免疫与不孕不育的初次研究》成果介绍  

Preliminary Analysis of Mycoplasma and Chlamydia Infection in Infertility in Xiangyang

作　　者：孙莉[1] 

机构地区：[1]襄阳职业技术学院医学院,湖北襄阳441021

出　　处：《襄阳职业技术学院学报》2015年第2期136-138,140,共4页Journal of Xiangyang Polytechnic

基　　金：湖北省教育厅科技计划项目(B20129401)

摘　　要：目的探究解脲脲原体(UU)、人型支原体(MH)和沙眼衣原体(CT)感染及抗精子抗体(As Ab)与不孕不育的关系。方法对襄阳市1 031例不孕不育患者的临床标本,分别采用培养法和PCR扩增法检测泌尿生殖道分泌物中的支原体和衣原体,用ELISA法检测血清As Ab,同时设立正常对照。结果不孕不育患者支(衣)原体感染率和As Ab阳性率均高于正常对照组,差异有统计学意义;支(衣)原体检测阳性患者血清As Ab总阳性率高于支(衣)原体检测阴性者;支原体感染类型以单纯UU感染最多见,不同类型感染者对抗生素的敏感程度亦不同。结论支(衣)原体感染和As Ab的产生与不孕不育密切相关,对不孕不育患者,应常规检测支(衣)原体和As Ab,以规避不孕不育风险;对支原体阳性者,根据药敏结果科学选择用药是提高治疗效果、防止耐药性产生的重要手段。Objective explore the relationship of ureaplasma urealyticum（UU）, Mycoplasma hominis（MH） and Chlamydia trachomatis（CT） infection and anti sperm antibody（As Ab） with infertility. Methods with the clinical specimens of 1031 patients with infertility were used in Xiangyang City, culture and amplification of Mycoplasma and Chlamydia detection urogenital secretions in PCR method, the detection of serum As Ab with ELISA method,and normally control. Result Mycoplasma and Chlamydia infection rate of the patients with infertility and the As Ab positive rate was higher than that in normal control group, and the difference has statistical significance;the total positive rate of mycoplasma detection in serum of patients with As Ab is higher than that of negative patients; UU infection is the most common in mycoplasma infection. Conclusion Mycoplasma and Chlamydia infection and the production of As Ab are closely related to infertility. Infertility patients should test Mycoplasma and Chlamydia and As Ab regularly to avoid the risk of infertility; Mycoplasma positive should take medicine scientifically based on the drug sensitivity to enhance the treatment effect and prevent the emergence of drug resistance.

关 键 词：解脲脲原体 人型支原体 沙眼衣原体 抗精子抗体 不孕不育 

分 类 号：R593.2[医药卫生—内科学]