献血者血液筛查检测中丙氨酸氨基转移酶与病毒性肝炎的相关性研究  

Correlation analysis between ALT and viral hepatitis in blood screening among blood donors

作　　者：熊姣梅[1] 郑欣[1] 杨爱莲[1] 魏天莉[1] 

机构地区：[1]深圳市血液中心,广东深圳518035

出　　处：《国际检验医学杂志》2015年第7期867-869,共3页International Journal of Laboratory Medicine

基　　金：深圳市科技计划项目(201302153)

摘　　要：目的研究无偿献血者丙氨酸氨基转移酶(ALT)不合格与乙型肝炎表面抗原(HBsAg)、丙型肝炎抗体(抗-HCV)检测的相关性,并探讨降低血液报废率的措施。方法对2009年1月1日至2013年12月31日深圳市血液中心330 633例无偿献血者血液标本进行ALT、HBsAg、抗-HCV检测并进行丙氨酸氨基转移酶与病毒性肝炎相关性分析。结果检测的330 633例标本中ALT检测阳性的标本932例,占献血总人次的0.282%;病毒性肝炎阳性标本2 965例,占献血总人次的0.897%,两者差异具有统计学意义(P<0.05)。ALT不合格,但病毒性肝炎阴性标本915例,占ALT不合格人数的98.176%;由ALT检测所造成的血液报废率为0.277%(915/330 633)。结论 ALT不合格率与病毒性肝炎检出率存在统计学差异,进行ALT检测的预期病毒性肝炎的符合率较低,许多假阳性导致了正常血液的报废。因此,ALT检测作为病毒性肝炎的辅助检查指标是否继续沿用仍有待商榷。Objective To study the correlation between alanie aminotransferase（ALT）unqualified samples and hepatitis B surface antigen（HBsAg）and hepatitis C virus antibody（anti-HCV）detection and to investigate an effective measure for reducing the discard rate of donated blood.Methods 330 633 blood samples donated by volunteers in Shenzhen Municipal Blood Center from January 1,2009 to December 31,2013 were performed the ALT,HBsAg and anti-HCV detection.Then the correlation between the detection results of ALT and viral hepatitis.Results Among 33 0633 donated blood samples,there were 932cases（0.282%）of ALT positive and 2 965cases（0.897%）of viral hepatitis positive,the differences were statistically significant（P〈0.05）.915 cases were unqualified in ALT,but negative in viral hepatitis,which accounting for 98.176% of all ALT unqualified samples;the blood discard rate generated by ALT disqualification was 0.277%（915/330633）.Conclusion Our study indicates that the statistical difference exists in the ALT unqualified rate and the viral hepatitis detection rate,conducting the ALT detection has the lower coincidence rate for expected viral hepatic,many false positive lead to the discard of normal blood.Therefore,whether to continue using the ALT detection as the auxillary detection indicator is still being negotiated.

关 键 词：无偿献血者 丙氨酸氨基转移酶 乙型肝炎表面抗原 丙型肝炎抗体 相关性 

分 类 号：R446.6[医药卫生—诊断学]