急性心肌梗死患者血清缺血修饰清蛋白和肌红蛋白检测水平分析  

Analysis of serum ischemia modified albumin and myoglobin in patients with acute myocardial infarction

作　　者：王斌[1] 

机构地区：[1]南充市第二人民医院检验科,四川南充637000

出　　处：《国际检验医学杂志》2015年第7期927-929,共3页International Journal of Laboratory Medicine

摘　　要：目的分析检测缺血修饰清蛋白（IMA）和肌红蛋白（MYO）水平在急性心肌梗死（AMI）早期诊断中的临床应用价值。方法在贝克曼库尔特AU680全自动生化分析仪上检测本院47例AMI患者和42例健康者（对照组）的血清IMA、MYO、乳酸脱氢酶（LDH）、肌酸激酶（CK）及肌酸激酶同工酶（CK-MB）的水平,同时检查心电图,并对其检测结果进行统计学分析比较。结果 AMI患者发生胸痛后0~〈6h,血清IMA和MYO水平明显高于对照组（P〈0.01）,血清LDH、CK和CK-MB水平也高于对照组（P〈0.05）;胸痛6h以前血清IMA和MYO水平明显高于胸痛6h以后（P〈0.05）,而LDH、CK和CK-MB水平差异无统计学意义（P〉0.05）。实验组IMA和MYO水平明显高于对照组（P〈0.01）,血清LDH、CK和CK-MB高于对照组（P〈0.05）。在AMI早期（0~6h）血清IMA和MYO阳性检出率均在78.0%以上,明显高于心电图、LDH、CK和CK-MB的检出率（P〈0.05）。结论 IMA和MYO可作为AMI早期诊断较理想的心肌缺血指标,且出现时间早、阳性检出率高。联合检测有助于AMI的早期确诊,为病情鉴别、治疗以及预后等提供可靠依据。Objective To analyze the clinical application value of the detection of ischemia modified albumin（IMA）and myoglobin（MYO）levels in the early diagnosis of acute myocardial infarction（AMI）.Methods The Beckman Kurt AU680 automatic biochemical analyzer was adopted to detect serum IMA,MYO,lactate dehydrogenase（LDH）,creatine kinase（CK）and creatine kinase isoenzyme MB（CK-MB）levels in 47 cases of AMI and 42 cases of healthy people（control group）.At the same time ECG was conducted.Then the detection results were statistically analyzed.Results The serum IMA and MYO levels in 0-6hafter chest pain occurrence in the AMI group was significantly higher than those in the control group（P〈0.01）,while serum LDH,CK and CKMB levels were higher than those in the control group（P〈0.05）;serum IMA and MYO levels at 6hbefore chest pain were significantly higher than at 6hafter chest pain（P〈0.05）,while LDH,CK and CK-MB had no statistical differences at 6hbetween before and after chest pain（P〉0.05）.The IMA and MYO levels in the experimental group were significantly higher than those in the control group（P〈0.01）,serum LDH,CK and CK-MB levels were higher than those in the control group（P〈0.05）.The positive detection rate of serum IMA and MYO at the early stage of AMI（0-6h）was above 78%,which was significantly higher than that of ECG,LDH,CK and CK-MB（P〈0.05）.Conclusion IMA and MYO can be used as the ideal index of myocardial ischemia in early diagnosis of AMI,moreover the earlier it appears,the higher the positive detection rate is.The combination detection of IMA and MYO conduces to the early diagnosis of AMI and provides the reliable basis for disease condition differentiation,treatment and prognosis.

关 键 词：急性心肌梗死 缺血修饰清蛋白 肌红蛋白 

分 类 号：R542.22[医药卫生—心血管疾病]