乙型肝炎病毒前S1抗原与HBV DNA和HBV-M及肝功能的相关性探讨  

Study on correlation between HBV Pre-S1 antigen with HBV DNA,HBV M and liver function in patients with hepatitis B

作　　者：李彩东[1] 吴斌[1] 陈锡莲[1] 段正军[1] 田鹏飞[1] 

机构地区：[1]兰州市第二人民医院肝病研究所,甘肃兰州730046

出　　处：《国际检验医学杂志》2015年第7期936-938,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨兰州地区乙型肝炎病毒(HBV)感染者血清中前S1抗原(Pre-S1Ag)与HBV DNA、HBV-M及肝功能之间的相关性。方法对905例HBV感染者(HBV感染组)及100例健康体检者(健康对照组)进行Pre-S1Ag、HBV-M、HBV DNA和肝功能检测。结果 905例标本中,Pre-S1Ag和HBV DNA阳性率分别为68.51%(620/905)和67.96%(615/905),差异均无统计学意义(χ2=30.064,P>0.05);570例HBeAg阳性组中,HBV Pre-S1阳性率为85.08%(485/570),显著高于HBeAg阴性组的Pre-SAg1阳性率40.30%(135/335),差异有统计学意义(χ2=108.881,P<0.01)。Pre-S1Ag阳性组与阴性组ALT、AST异常率分别为53.22%、25.96%和51.29%、32.98%,差异有统计学意义(χ2ALT=53.148,P<0.001,χ2AST=66.635,P<0.001)。结论 Pre-S1Ag是乙肝病毒感染与复制的可靠指标,与HBV-DNA阳性相关度高,是对HBeAg的重要补充和加强,可为指导临床治疗提供更及时可靠的实验依据。Objective To investigate the correlations on hepatitis B virus（HBV）preS1-antigen（pre-S1Ag）with HBV-DNA,HBV markers（HBV M）and liver function in the patients with hepatitis B.Methods The markers,preS1-Ag,HBV-DNA and liver function were determined by CLIA and PCR in 905 patients with hepatitis B（HBV infection group）and 100 healthy persons（healthy control group）.Results Among 905 samples,the positive rates of preS1-Ag and HBV DNA were 68.51%（620/905）and67.96%（615/905）,there was no statistically significant difference between them（χ2=30.064,P〈0.05）;the positive rates of preS1 Ag in 570 patients with HBeAg positive were 85.08%（485/570）,which was significantly higher than 40.30%（135/335）in 335 patients with HBeAg negative,the difference was statistically significant（χ2=108.881,P〈0.01）.The abnormal rates of ALT and AST in the Pre-S1 Ag positive and negative groups were 53.22%,25.96% and 51.29%,32.98%,respectively,the differences between them were statistically significant（χ2ALT=53.148,P〈0.001,χ2AST=66.635,P〈0.001）.Conclusion Pre-S1 Ag is a reliable index of the HBV infection and duplication and is highly correlated with HBV-DNA positive,which is important supplement and strengthening and can provide more timely and reliable experiment basis for guiding the clinical treatment.

关 键 词：乙型肝炎病毒 HBV前S1抗原 HBV血清标志物 HBV-DNA 

分 类 号：R512.62[医药卫生—内科学]