自制一级微铜圈栓塞兔肾动脉的实验研究  

Experimental study of rabbits′renal artery embolization with first level copper coils

作　　者：姜华[1] 赵莉莉[1] 濮进敏[1] 童玉云[1] 李迎春[1] 王家平[1] 赵睿敏[1] 李松蔚[1] 

机构地区：[1]昆明医科大学第二附属医院放射科介入室,云南昆明650101

出　　处：《医学影像学杂志》2015年第3期521-524,共4页Journal of Medical Imaging

基　　金：云南省卫生内设研究机构项目(2010NS074)

摘　　要：目的观察自制一级微铜圈栓塞兔肾动脉的病理改变,为临床提供实验依据。方法用直径0.1～0.23mm导电用铜丝（纯度99.9%）制成直径0.48～0.74mm的一级微铜圈,经3F微导管释放栓塞兔肾动脉末梢支,于栓塞术后不同时间观察血管闭塞情况和病理学改变。结果栓塞术后3天、1周、2周、4周、6周和12周,动脉造影血管管腔闭塞时可见到血栓的形成。结论自制一级微铜圈诱发血栓形成,血栓机化,血管壁炎性病变,管腔闭塞,栓塞组织缺血性梗死,栓塞血管少量可再通。Objective The purpose of this study was to evaluate the histopathologic manifestation o f the dog renal atery embolized with self-made first level copper coils,and to provide the experimental evidence fo rclinic.Methods First level of pure copper micro-coil（Φ：0.48～0.74mm）made from 0.1～0.23 mm diameter pure copper wire.Renal artery embolization with first level pure copper coil was performed through 3Fcatheter in rabbits.After the embolization,the arteriography and the tissue histology were respectively evaluated at different time intervals.Results After the embolization for 3days,1w,2w,4w,6wand 12 w,arteriography vascular lumen thrombosis can be seen when the occlusion was formed.Conclusion Self-made first level copper coils induced thrombosis and a severe form panarteritis.Organization of the thrombos then take place and a complete occlusion of the vessels occurs,leading to severe ischemia as infarction of embolized area.

关 键 词：金属铜 弹簧圈 栓塞动脉 肾脏 家兔 

分 类 号：R815[医药卫生—放射医学] R-332[医药卫生—临床医学]