蛋白酶3及其与疾病的关系研究进展  

Research Advances on Proteinase 3 and Its Relationship With Diseases

作　　者：刘广花 邓莉[2] 彭礼飞[1,2] 

机构地区：[1]广东省医学分子诊断重点实验室,东莞523808 [2]广东医学院寄生虫学和临床寄生虫检验学教研室,湛江524000

出　　处：《生物化学与生物物理进展》2015年第3期244-253,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81171599);广东省高等学校科技创新项目(2013KJCX0087);广东医学院科技创新团队项目(STIF201107)资助~~

摘　　要：蛋白酶3(proteinase 3,PR3)是中性粒细胞分泌的主要丝氨酸蛋白酶之一,其生物学功能广泛,不仅能降解多种组织蛋白,还可通过加工细胞因子、受体等调控炎症反应,与慢性炎症性疾病如血管炎性肉芽肿病、慢性阻塞性肺疾病、肺囊肿性纤维症的发生发展密切相关,可能作为疾病防治靶点.本文主要综述了PR3的生物学功能及其在疾病中的可能作用机制,期望为相关疾病的防治提供新的思路.Proteinase 3 is one of the major serine proteases secreted by neutrophils with multiple biological functions. It can degradate tissue proteins, process cytokines and receptors, thus contributing to the regulation of inflammatory and immune responses, and play important roles in the occurrence and development of chronic inflammatory diseases, such as granulomatosis with polyangiitis, chronic obstructive pulmonary diseases and pulmonoary fibrosis. In this reviews, we describle the biological functions of PR3 and its roles in human diseases,which might provide a new insight for the prevention and treatment of human diseases.

关 键 词：蛋白酶3 细胞因子 抑制剂 炎症性疾病 血管炎性肉芽肿病 慢性阻塞性肺疾病 肺囊肿性纤维症 

分 类 号：Q5[生物学—生物化学] R3[医药卫生—基础医学]