癌蛋白YAP1的研究进展  

The Current Progress of Oncoprotein YAP1

作　　者：郭海强[1] 刘同阳 贾舒婷[1] 罗瑛[1] 

机构地区：[1]昆明理工大学医学院 [2]昆明理工大学生命科学与技术学院

出　　处：《生物化学与生物物理进展》2015年第3期254-259,共6页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(31170735)~~

摘　　要：Yes相关蛋白1(Yes-associated protein 1,YAP1)是Hippo信号通路(Hippo pathway)中的一个分子.早期研究人员发现,在Hippo信号通路正常的情况下,YAP1处于非激活状态;当Hippo信号通路中的某些分子出现突变时,YAP1处于超激活状态.此时,超激活状态下的YAP1可以促进细胞增殖、转移、生存(survival)以及维持干细胞活性.由于YAP1的超激活可以促进肿瘤的发生与发展,因此,YAP1被定义为一个癌蛋白.近期,研究者发现,YAP1的突变体与小细胞肺癌病人的存活率有一定关系,YAP1与链蛋白(catenin)、Kras相互作用,调节肿瘤细胞的转移侵袭能力,此外,部分micro RNA也与YAP1有相互作用.基于YAP1的功能,可以制定一些抗癌策略,寻找一些抗癌靶点.本文对当前YAP1的研究进行综述,为肿瘤治疗的基础及临床研究提供一些依据.YAP1（Yes-associated protein 1）is a molecular of Hippo pathway. In early studies, researchers found that YAP1 was inactive when Hippo pathway was well functional. When some molecules mutated in Hippo pathway, YAP1 was hyperactivated. Hyperactivated YAP1 could promote cell proliferation, metastasis, cell survival and maintain the activity of stem cell. Because hyperactivated YAP1 can promote the occurrence and progress of tumor, YAP1 was defined as an oncoprotein. Recently, researchers found that YAP1 variants were associated with survival rates of small-cell lung cancer patients. YAP1 interacted with catenin and Kras to regulate infiltration and metastasis of cancer cell. And some micro RNAs could interact with YAP1. Based on the function of YAP1, we can find some therapeutic strategies and targets for cancer treatment. This paper summarize the studies of YAP1 and provide some evidence for basic and clinical research of cancer therapy.

关 键 词：YAP1 Hippo信号通路 超激活 增殖 转移 

分 类 号：Q7[生物学—分子生物学] Q5