计算机辅助设计定制羟基磷灰石/医用树脂假体重建颅颌面外形的应用  

Application of computer-aided design of customized hydroxyapatite / medical resin prosthesis for reconstruction of craniofacial shape

作　　者：柳稚旭[1] 张雷[1] 李彪[1] 沈舜尧[1] 张诗雷[1] 沈国芳[1] 王旭东[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颅颌面科.上海市口腔医学重点实验室,上海200011

出　　处：《生物医学工程与临床》2015年第2期144-148,共5页Biomedical Engineering and Clinical Medicine

摘　　要：目的探讨计算机辅助设计定制羟基磷灰石假体/可塑性医用树脂对恢复颧上颌骨畸形患者外形的精确性及安全性。方法选择2008年1月至2014年3月上海交通大学医学院附属第九人民医院颅颌面缺损畸形患者17例,其中男性5例,女性12例;年龄18~44岁,平均年龄25.6岁。接受计算机辅助设计定制羟基磷灰石假体治疗。术后6个月CT扫描重建影像与术前虚拟设计进行几何学差异分析,判断植入物设计的精确性,并统计患者并发症的发生。结果 17例患者中,除1例因术后反复感染取出植入物外,余16例恢复良好,均未发生严重并发症。几何学差异分析显示,差异率为90.5%±3.1%,患者对面型表示满意。结论计算机辅助设计定制羟基磷灰石假体/可塑性医用树脂治疗颅颌面缺失具有较高的精确性和安全性,可为颅颌面缺损修补的推荐方案之一。Objective To investigate the efficiency and safety of computer-aided design / computer-aided manufacturing hydroxyapatite / epoxide acrylate maleic in treatment of craniomaxillofacial bone defects. Methods A total of 17 patients with craniomaxillofacial bone defects were enrolled, which included 5 males and 12 females, aged 18- 44 years old with mean age of 25.6years old. All of them were treated with compute-aided design / computer-aided manufacturing hydroxyapatite / epoxide acrylate maleic from January 2008 to March 2014. The geometry difference analysis was performed between CT scanning image reconstruction and preoperative virtual design after 6-month operation. The accuracy of implant and complications were documented. Results Sixteen cases were recovery but due to postoperative recurrent infection 1 case removal implant without severe complication occurred. The geometry differences analysis showed differences rate was 90.5 % ± 3.1 %, and the patients were satisfied. Conclusion It is demonstrated that computer-aided design / computer-aided manufacturing hydroxyapatite /epoxide acrylate maleic is an efficient, accurate and safe method to craniomaxillofacial deformities, which is one of the recommended schemes for repairing craniomaxillofacial defect.

关 键 词：计算机辅助设计/计算机辅助制造 羟基磷灰石/可塑性医用树脂 颅颌面骨缺损 骨重建 

分 类 号：R318.08[医药卫生—生物医学工程]