阿德福韦酯致不良反应回顾性分析  

A Retrospective Analysis of Adverse Drug Reaction Caused by Adefovir Dipivoxil

作　　者：李娟[1] 厉彦翔[1] 林蓉[1] 曹平虎 

机构地区：[1]西安交通大学医学部,710061

出　　处：《中外女性健康研究》2015年第3期9-10,共2页Women＇s Health Research

摘　　要：目的：探讨阿德福韦酯在临床使用中不良反应发生的规律和特点，为临床安全用药提供依据。方法：以“阿德福韦酯”为关键词，检索2009～2014年万方数据库，检索出关于阿德福韦酯药品不良反应共计59例，并进行回顾性分析。结果：长期使用阿德福韦酯可引起严重不良反应，以低磷性骨软化病、肾脏损害为主，经停药、补充磷、钙等治疗后预后良好。结论：应加强对阿德福韦酯不良反应的监测，尽早完善国产说明书关于低磷性骨软化症不良反应的警示。Objective： To study the regularities and characteristics of adefovir dipivoxil-induced adverse drug reaction for clinical reference of safe use of drugs. Methods By retrieving Wanfang database during 2009 to 2014 with the key words＂adefovir dipivoxil＂, a total of 25 papers （59 cases） were collected and which were analyzed retrospectively. Results Long term use of adefovir dipivoxil might cause a lot of adverse drug reactions, such as hypophosphatemia osteomalacia and kidney damage. Serious adverse reactions may be cured by terminate, supplement phosphorus, calcium and so on. Conclusion：It is emergency to strengthen the monitoring of the adverse reactions induced by adefovir dipivoxil. Warning information on adverse reactions of low phosphorus should be introduced in the domestically produced adefovir dipivoxil as soon as possible.

关 键 词：阿德福韦酯 不良反应 文献分析 

分 类 号：R961[医药卫生—药理学]