血清降钙素原检测在ICU多药耐药菌感染患者治疗中的应用  

Application of serum procalcitonin detection in the treatment of patients infected by multidrug resistant organisms in ICU

作　　者：王娇[1] 陈梦燕[1] 黄静[1] 

机构地区：[1]义乌市中心医院ICU,浙江义乌322000

出　　处：《中华医院感染学杂志》2015年第7期1467-1469,共3页Chinese Journal of Nosocomiology

基　　金：浙江省科技厅研究基金资助项目(2013072546ZJ)

摘　　要：目的研究ICU多药耐药感染患者应用血清降钙素原(PCT)检测方法,以指导ICU多药耐药感染患者抗菌药物治疗的作用及意义。方法选取2013年1月-2014年1月确诊为ICU多药耐药感染的102例患者进行研究分析,随机分为对照组与观察组,各51例;对比两组患者抗菌药物使用时间、使用剂量及炎性反应进行分析,采用SPSS16.0软件进行统计分析。结果抗菌药物使用时间观察组(6.6±1.2)d、较对照组的(9.8±1.9)d少,且不同时间内抗菌药物的使用率较对照组明显减少;炎性水平指标显示观察组的PCT水平(32.6±9.6)ng/L低于对照组的(98.5±21.4)ng/L,对照组CRP(11.5±4.1)μg/L明显高于观察组的(5.4±2.2)μg/L,白细胞计数观察组(15.5±3.7)×109/L同样低于对照组(32.4±5.2)×109/L,差异有统计学意义(P<0.05)。结论对ICU多药耐药菌感染抗菌药物应用中PCT检测可有效降低抗菌药物的使用量,缓解了医患的内外在压力。OBJECTIVE To investigate the methods of serum procalcitonin detection in the treatment of patients infected by multi-drug resistant organisms so as to guide the therapy of antibiotics in those patients .METHODS From Jan .2013 to Jan .2014 ,totally 102 cases of patients infected by multi-drug resistant organisms in ICU were randomly divided into control group and observation group with 51 cases each .The using time ,dosage and inflammatory response of the antibiotics used by the two groups of patients were compared and analyzed .All data were statistically analyzed by SPSS 16 .0 software .RESULTS The use time of antimicrobial agents in the observation group was （6 .6 ± 1 .2） d ,which was less than the control group of （9 .8 ± 1 .9） d ,and the usage rate of antibiotics at different time in the observation group decreased obviously compared with the control group .And the inflammatory indicator showed that PCT level in the observation group was （32 .6 ± 9 .6） ng/L ,which was lower than the control group of （98 .5 ± 21 .4） ng/L .The CRP in the control group was （11 .5 ± 4 .1）μg/L ,significantly higher than that of the observation group of （5 .4 ± 2 .2）μg/L .The white blood cell count in the observation group was （15 .5 ± 3 .7） × 10^9/L ,which was also lower than the control group with （32 .4 ± 5 .2）×10^9/L .The difference was significant （P〈0 .05） .CONCLUSION Application of serum procalcitonin in detecting antibiotic resistance to multi-drugs in ICU can effectively reduce the amount of use of antimicrobial drugs so as to ease the pressure inside and outside the doctor-patient relations .

关 键 词：血清降钙素原 重症监护病房 多药耐药菌 感染 抗菌药物 

分 类 号：R446[医药卫生—诊断学]