泌尿系统感染假丝酵母菌属分布与药敏分析  

The clinical distribution and antifungal susceptibility tests of Candidaspecies in urinary infection

作　　者：王宏伟[1] 许俊华[1] 孙美玲[1] 李慧[1] 

机构地区：[1]青岛大学附属医院检验科,山东青岛266101

出　　处：《中华医院感染学杂志》2015年第7期1487-1489,共3页Chinese Journal of Nosocomiology

基　　金：青岛市科技计划基础研究基金项目(09-1-3-70-JCH)

摘　　要：目的研究泌尿系统感染患者尿液标本分离的假丝酵母菌属等真菌的感染特点、分布及其对抗真菌药物敏感性,为临床治疗提供参考依据。方法回顾性分析2009年12月1日-2012年11月30日住院患者尿液标本中分离鉴定242株真菌,计算菌种构成比、科室分离率,统计分析主要致病真菌的药敏结果,采用SPSS17.0软件进行统计分析。结果共检测出242株真菌,以白色假丝酵母为主,共85株35.1%;其分布科室以综合ICU为主,共80株占33.1%;白色假丝酵母菌、热带假丝酵母菌、光滑假丝酵母菌对两性霉素B敏感,敏感率为100.0%。结论尿路感染的假丝酵母菌属发病率随着人口老龄化及各种医疗行为干预导致免疫低下患者有增高的趋势,应引起临床医师的高度关注;及早进行微生物学检测并根据药敏结果选择抗真菌药物,可有效地控制该类真菌引起的感染。OBJECTIVE To investigate the characteristics,distribution of fungi such as Candidain urine samples from patients with urinary infections and antifungal susceptibility,so as to improve the level of clinical treatment.METHODS A retrospective analysis was conducted on 242 strains of fungi isolated and identified from urine samples from inpatients during Dec.1st,2009 to Nov.30 th,2012.The constituent ratio and the department distribution of strain species were calculated and the drug susceptibility of main pathogens were summarized and analyzed.The software SPSS17.0was used for statistical analysis.RESULTS Totally 242 fungi were detected,mainly including Candida albicans（85strains,35.1%）.The pathogens were mainly distributed in the integrated ICU（80strains,33.1%）.C.albicans,Candida tropicalis and Candida glabrata were sensitive to amphotericin B with the sensitive rate of 100.0%.CONCLUSIONThe incidence of Candidaurinary infections increases along with the increased survival rate of immunocompromised patients due to population aging and a variety of medical intervention,which should be paid much attention to by clinicians.Early antifungal susceptibility test and selection of antifungal drugs accordingly can be helpful to control urinary infection caused by these fungi.

关 键 词：假丝酵母菌属 泌尿道感染 药敏试验 

分 类 号：R379[医药卫生—病原生物学]