支气管动脉灌注治疗中心型肺癌患者阻塞性肺炎疗效观察  

Clinical observation of bronchial arterial infusion in the treatment of central-type lung cancer complicated with obstructive pneumonia

作　　者：张伟[1] 成强 李学达[1] 杨莉莉[1] 李子祥[1] 

机构地区：[1]青岛大学医学院附属医院黄岛院区介入医学中心,山东青岛266003 [2]解放军401医院干一科,山东青岛266071

出　　处：《中华医院感染学杂志》2015年第7期1569-1571,共3页Chinese Journal of Nosocomiology

基　　金：山东省科技厅研究基金资助项目(201305DX-9)

摘　　要：目的探讨中心型肺癌合并阻塞性肺炎感染的病原菌分布、耐药率,调查介入治疗的效果,为临床提供诊治参考依据。方法选取2012年12月-2014年1月收治的肺癌并发阻塞性肺炎患者124例,随机分为普通组和观察组各62例,普通组给予单纯支气管灌注治疗,观察组在普通组基础上根据药敏结果使用针对性抗菌药物灌注治疗,对比治疗效果,数据采用SPSS 16.0软件进行统计分析。结果 124例患者检出148株病原菌,以革兰阴性菌为主,共72株占48.65%;患者治疗总有效率观察组为95.16%,明显高于普通组的83.87%,两组比较差异有统计学意义(P<0.05)。结论中心型肺癌合并阻塞性肺炎感染患者,根据药敏结果使用针对性抗菌药物灌注治疗临床效果显著确切,值得临床推广应用。OBJECTIVE To investigate the pathogen distribution and drug resistance rate of central-type lung cancer complicated with obstructive pneumonia and evaluate the effect of interventional therapy so as to provide references for clinical diagnosis and treatment.METHODS From Dec.2012 to Jan.2014,124 cases of patients with centraltype lung cancer complicated with obstructive pneumonia were selected and randomly divided into control group and observation group.The control group was adopted bronchus infusion alone while the observation group was treated with targeted antibiotics to give infusion according to drug sensitivity results on the basis of this.The curative effect was compared.And SPSS 16.0was adopted for statistical analysis.RESULTS Totally 148 strains of pathogenic bacteria were detected from 124 patients.Gram-negative bacteria hold for a majority with 72 strains,accounting for 48.65%.In the observation group,the total effective rate was 95.16 %,which was significantly higher than the control group with the rate of 83.87%（P〈0.05）.CONCLUSIONThe infusion of targeted antibiotics according to the drug sensitivity results has clear and remarkable curative effect in treating patients with central-type lung cancer complicated with obstructive pneumonia so that it is worthy to be widely applied in clinic.

关 键 词：中心型肺癌 阻塞性肺炎 病原菌 耐药率 

分 类 号：R563.1[医药卫生—呼吸系统]