中枢神经系统医院感染患者血清心肌酶与一氧化氮变化的临床研究  

Clinical studies of the changes of serum myocardial enzyme and nitric oxide in patients suffered from central nervous system nosocomial infection

作　　者：李敏[1] 苏传生[1] 张红[1] 

机构地区：[1]山东省高唐县人民医院神经内二科,山东高唐县252800

出　　处：《中华医院感染学杂志》2015年第7期1574-1575,1606,共3页Chinese Journal of Nosocomiology

基　　金：山东省卫生厅重点规划基金资助项目(SW-2010B-029)

摘　　要：目的探讨中枢神经系统医院感染患者心肌酶以及一氧化氮(NO)水平的变化,为中枢神经系统感染早期诊断、利于改善预后提供参考依据。方法选取2011年4月-2013年12月中枢神经系统医院感染患者69例作为观察组,同期健康体检人员70名作为对照组,对两组人员血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)、一氧化氮(NO)以及一氧化氮合成酶(NOS)水平进行检测并比较,所有数据采用SPSS13.0软件进行统计分析。结果观察组患者的CK、CK-MB、LDH及α-HBDH明显高于对照组,差异有统计学意义(P<0.05);患者NO及NOS观察组分别为(56.38±5.09)μmol/L和(58.22±4.13)U/ml,对照组分别为(41.13±4.33)μmol/L和(29.56±3.01)U/ml,两组比较差异有统计学意义(P<0.05)。结论通过检测血清心肌酶和NO水平对中枢神经系统感染进行早期诊断和判断严重程度,从而尽早采取措施进行治疗,以改善患者的预后。OBJECTIVE To investigate changes of cardiac enzymes and nitric oxide levels in patients suffered from central nervous system nosocomial infections,so as to provide clinical reference for the early diagnosis and improved prognosis of central nervous system infections.METHODS Totally 69 patients with central nervous system infection in the hospital from Apr.2011 to Dec.2013 were selected as observation group and another 70 cases of healthy people as control group.The levels of serum creatine kinase（CK）,creatine kinase isoenzyme（CK-MB）,lactate dehydrogenase（LDH）,α-hydroxybutyrate dehydrogenase（α-HBDH）,nitric oxide（NO）and nitric oxide synthase（NOS）were measured and compared,and SPSS 13.0was adopted for statistical analysis.RESULTS The levels of CK,CK-MB,LDH andα-HBDH in the observation group were significantly higher than the control group（P〈0.05）.And NO and NOS levels in the observation group were（56.38±5.09）μmol/L and（58.22±4.13）u/ml respectively,while（41.13±4.33）μmol/L and（29.56±3.01）u/ml in the control group.The difference was statistically significant（P〈0.05）.CONCLUSIONSerum myocardial enzymes and NO levels should be detected for early diagnosis and judgment of disease degree of central nervous system infections so as to take measures for treatment and improving prognosis.

关 键 词：中枢神经系统 医院感染 心肌酶 一氧化氮 

分 类 号：R181.32[医药卫生—流行病学]