抗生素骨水泥预防老年人工髋关节置换术后深部感染的临床研究  

Clinical studies of the role of antibiotic bone cement in the prevention of deep infections in old people after adopting artificial hip replacements

作　　者：赵忠福[1] 李晓光[1] 刘金煜[1] 

机构地区：[1]齐齐哈尔医学院第二附属医院骨外科,黑龙江齐齐哈尔161006

出　　处：《中华医院感染学杂志》2015年第7期1623-1625,共3页Chinese Journal of Nosocomiology

基　　金：黑龙江省卫生厅基金资助项目(HW-2009A-034)

摘　　要：目的研究抗生素骨水泥对老年人工髋关节置换术后深部感染的临床预防效果,降低老年人工髋关节置换术后深部感染的感染率。方法对2013年进行人工关节置换手术的78例老年患者分成单纯骨水泥假体组、抗生素骨水泥假体组和生物性假体组3个组,每组各26例,进行手术前和手术后的第1天、第1周和第1个月对患者进行C-反应蛋白和红细胞的沉降率检验,对手术后患者的感染情况进行观察分析。结果 3组患者中单纯骨水泥假体组出现1例深部感染,感染率为3.85%;抗生素骨水泥和生物性假体组未出现感染,在手术后的第1周和1个月后检查C-反应蛋白和红细胞沉降,组间比较差异均无统计学意义;1个月后抗生素骨水泥组、单纯骨水泥组和生物性假体组的血沉分别为:(21.67±4.03)、(30.17±4.79)、(21.58±3.87)mm/h,生物性假体组和抗生素骨水泥组血沉均明显低于单纯骨水泥组,差异有统计学意义(P<0.05)。结论抗生素骨水泥组在预防老年人工髋关节置换术后的深部感染情况有一定的疗效,对于易感人群特别是老年人有重要的临床价值。OBJECTIVE To study the clinical efficacy of antibiotic bone cement in the prevention of deep infections in old people after adopting artificial hip replacements,so as to reduce the infection rate of deep infections of them.METHODS All the 78 elder patients who would receive artificial hip replacements in 2013 were divided into pure bone cement prosthesis group,antibiotic bone cement prosthesis group,and biological prosthesis group with 26 cases each.On the first day,the first week and the first month after surgery,blood tests were conducted to examine C-reactive protein and erythrocyte sedimentation rate,and the postoperative infection condition was analyzed.RESULTS One case was found to be deep infected in the pure bone cement prosthesis group,the infection rate was3.85%.While no infected case was found in the biotic bone cerement group and biological prosthesis group.The results of C-reactive protein level and erythrocyte sedimentation rate in the first week and the first month after the surgery were compared but no statistical significant were found.One month later,the erythrocyte sedimentation in antibiotic bone cement group,pure ESR bone cement group and biological prosthesis group were：（21.67±4.03）,（30.17±4.79）,and（21.58±3.87）mm/h respectively.The erythrocyte sedimentation rate of biological prosthesis group and antibiotic bone cement group were significantly lower than the pure bone cement group（P〈0.05）.CONCLUSION Antibiotic bone cement group has a certain clinical efficacy in the prevention of infections of old people after artificial hip replacements,hence has significant clinical value on susceptible population especially the aged.

关 键 词：抗生素骨水泥 髋关节置换术 深部感染 临床研究 

分 类 号：R619.3[医药卫生—外科学]