关节腔内注射富血小板自体血浆与玻璃酸钠治疗膝骨关节炎临床效果比较  

Comparative study of the physicochemical indexes and clinical effects of platelet-rich plasma and sodium hyaluronate on knee osteoarthritis treatment

作　　者：刘小刚[1] 谢志杰[1] 邓强[2] 

机构地区：[1]青岛大学医学院附属威海医院骨科,山东省威海264200 [2]新疆医科大学第一附属医院骨科

出　　处：《中国基层医药》2015年第6期828-830,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：国家自然科学基金项目（81460481）

摘　　要：目的：比较关节腔内注射富血小板自体血浆与玻璃酸钠治疗膝骨关节炎临床效果。方法100例膝骨关节炎患者按治疗方法不同将其分为研究组50例（富血小板血浆治疗）与对照组50例（玻璃酸钠治疗），将两组患者治疗后的效果进行对比，并采用Lysholms评分标准对患者膝关节活动功能进行评分，采用视觉模拟方法对患者膝关节疼痛进行评分。结果研究组患者治疗优良率（98．0％）与对照组（94.0％）差异无统计学意义（P＞0．05）；研究组患者膝关节活动功能评分[（76．81±9．24）分]明显优于对照组[（60．46±7．41）分]，差异有统计学意义（t＝－9．76，P＜0．05）；研究组患者膝关节疼痛程度评分[（1．91±0．88）分]与对照组[（3．58±0．85）分]相比，差异有统计学意义（t＝9．65，P＜0．05）。结论给予富血小板血浆和玻璃酸钠膝腔内关节注射治疗骨性关节炎，均能够有效缓解患者膝关节疼痛及活动受限等临床症状，提高治疗优良率，但是富血板血浆治疗效果更显著，值得推广。Objective To compare the clinical effect of platelet rich plasma and sodium hyaluronate in the treatment of knee osteoarthritis .Methods According to the different treatment methods ,100 patients with knee osteo-arthritis were divided into the control group （ for treatment of platelet rich plasma ） and study group （ for treatment of sodium hyaluronate）,each group 50 cases.The treatment effect would be compared between two groups ,and the patients were scored knee joint active function using Lysholms score standard ,using visual analogue score method on patients with knee joint pain .Results The excellent and good rate had no significant difference between the study group（98.0%） and control group（94.0%）（P〉0.05）;The knee joint activity of study group （76.81 ±9.24） was significantly better than that of the control group （60.46 ±7.41）,the difference was statistically significant （t =-9.76,P〈0.05）;the knee joint pain degree of the study group （1.91 ±0.88） was lower than that of the control group （3.58 ±0.85）,the difference was statistically significant （t=9.65,P〈0.05）.Conclusion Platelet rich plasma and the knee joint injection of sodium hyaluronate in the treatment of osteoarthritis were able to effectively alle -viate knee joint pain ,activity limitation and other clinical symptoms ,improve the curative rate ,but the treatment effect of sodium hyaluronate is more remarkable ,which is worthy of promotion .

关 键 词：血蛋白质类 玻璃酸钠 骨关节炎 注射 关节内 

分 类 号：R684.3[医药卫生—骨科学]