急诊早期机械通气联合支气管肺泡灌洗及药物介入治疗对重症哮喘的疗效研究  

Clinical research of emergency early mechanical ventilation and bronchoalveolar lavage and drug intervention to prognosis of severe asthma

作　　者：程俐[1] 徐强[1] 黄健[1] 

机构地区：[1]滕州市中医医院重症医学科,山东省滕州277500

出　　处：《中国基层医药》2015年第6期857-859,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：研究急诊早期机械通气联合支气管肺泡灌洗及药物介入对重症哮喘的疗效。方法选取重症哮喘患者140例，按照随机数字表法分为研究组和对照组，每组70例。对照组给予早期机械通气治疗，研究组在对照组的基础上给予患者支气管肺泡灌洗及药物介入治疗。比较两组临床疗效、肺泡功能、病情好转时间和住院时间。结果研究组总有效率92．9％（65／70），显著高于对照组的81．4％（57／70），两组差异有统计学意义（χ2＝12．382，P＜0．05）；研究组1 s用力呼气容积（ FEV1）、用力肺活量（ FVC）和FEV1／FVC改善显著优于对照组，两组差异均有统计学意义（t＝9．098、10．382、11．204，均P＜0．05）；研究组病情好转时间和住院时间均显著短于对照组，两组差异有统计学意义（t＝9．898、12．393，均P＜0．05）。结论急诊早期机械通气联合支气管肺泡灌洗及药物介入对重症哮喘具有较好的临床疗效，能显著改善患者的临床症状。Objective To study the clinical efficacy of emergency early mechanical ventilation and bron -choalveolar lavage and drug intervention to severe asthma .Methods 140 cases with severe asthma were selected ,the patients were divided into the study group and the control group according to a random number table ,70 cases in each group,the control group were received early mechanical ventilation ,the study group were given bronchoalveolar lavage and interventional therapy on the basis of the control group ,clinical efficacy ,alveolar function ,her condition improved and hospital stay of the two groups were compared .Results The total efficiency of the study group were 92.9%（65/70） significantly higher than 81.4%（57/70） in the control group,the difference was statistically significant （χ2 =12.382,P〈0.05）;Forced expiratory volume in one second （FEV1）,forced vital capacity （FVC） and FEV1/FVC of the study group were significantly better than that of the the control group ,the difference was statistically significant （ t=9.098,10.382,11.204,all P〈0.05）;Condition improved and hospital stay of the study group were significantly shorter than that of the control group,the difference was statistically significant （t=9.898,12.393,all P〈0.05）. Conclusion Emergency early mechanical ventilation and bronchoalveolar lavage and drug intervention to severe asthma had better clinical efficacy ,which can significantly improve the clinical symptoms of the patient .

关 键 词：机械通气 支气管肺泡灌洗 重症哮喘 疗效 

分 类 号：R562.25[医药卫生—呼吸系统]