壳聚糖凝胶(Ⅲ型)对痔切除术后创面的影响  

Effects of chitosan gel(Ⅲ type) in postoperative wound of hemorrhoidectomy

作　　者：黎小平[1,2] 黄宗海[1] 胡立春 

机构地区：[1]南方医科大学附属珠江医院,广东广州510000 [2]佛山市南海区第三人民医院,广东佛山528244

出　　处：《中国新药与临床杂志》2015年第3期233-235,共3页Chinese Journal of New Drugs and Clinical Remedies

基　　金：佛山市医学类科技攻关项目(201308149)

摘　　要：目的评价痔切除术后应用壳聚糖凝胶的临床疗效。方法 122例拟行Milligan-Morgan术的混合痔患者,分为两组。试验组63例,术后每日用壳聚糖凝胶均匀涂抹在创面;对照组59例,术后外用马应龙痔疮膏;疗程7 d。评估两组术后第1、3、5、7日患者疼痛、出血、水肿、坠胀感症状评分,计算总分。术后1年回访,评估临床疗效。结果术后第1日,两组症状评分无显著差异(P>0.05)。试验组术后3、5、7日症状评分总分均低于对照组,差异有显著意义(P<0.05)。术后1年,试验组有效率95%(60/63),对照组为92%(54/59),两组临床疗效无显著差异(P>0.05)。两组均未出现术后严重并发症。结论壳聚糖凝胶缓解Milligan-Morgan术后早期不适症状疗效优于马应龙痔疮膏,远期疗效与后者类似。AIM To explore the clinical effects of chitosan gel in postoperative wound of hemorrhoidectomy.METHODS A total of 122 patients who received Milligan-Morgan were divided into trial group（n = 63） and control group（n = 59）.The trial group was treated with chitosan gel in postoprerative wound for 7 days,while the control group used Mayinglong hemorrhoids ointment.Score of symptoms（such as pain,bleeding,edema,anus belly） were respectively recorded on the first day,the third day,the fifth day,the seventh day after hemorrhoidectomy,and then the total score was calculated.The clinical curative effect was evaluated through review after one year.RESULTS Symptom scores of two groups had no significant difference（P 〉0.05） in the first day after surgery.Symptom scores of the trial group were lower than those in the control group on the third day,the fifth day,the seventh day after surgery,and the difference was significant（P〈0.05）.The effective rate was 95%（60/63） in the trial group,while it was 92%（54/59） in control group.There was no significant difference in clinical curative effect between two groups（P〉0.05）.No serious complications occurred in two groups.CONCLUSION Chitosan gel is better than Mayinglong hemorrhoids ointmento in alleviation earlypostoperative discomfort,while the long-term curative effect is similar to the latter.

关 键 词：壳聚糖 痔 外科手术 Milligan-Morgan手术 

分 类 号：R982[医药卫生—药品]