肿瘤坏死因子-α基因G-308A多态性与心肌梗死相关性的Meta分析  

Meta-Analysis of Association Between Tumor Necrosis Factor-alpha G-308A Polymorphism and Myocardial Infarction

作　　者：华先平[1] 王贤明[2] 操传斌[1] 钱进[1] 谢建[1] 彭俊秋[1] 张振建[1] 

机构地区：[1]湖北医药学院附属随州医院心血管内科,湖北随州441300 [2]湖北医药学院附属随州医院超声科,湖北随州441300

出　　处：《湖北医药学院学报》2015年第1期31-37,共7页Journal of Hubei University of Medicine

摘　　要：目的:肿瘤坏死因子-α(TNF-α)基因G-308A多态性与心肌梗死(myocardial infarction,MI)易感性的研究结果仍有争议,本文采用Meta分析的方法进行评价。方法:检索Pub Med、Embase及中国知网,截止时间为2014年4月20日。对合格研究进行资料提取并采用Comprehensive Meta-Analysis V2软件进行Meta分析。结果:最终纳入12篇文献共计13项病例-对照研究,包含病例6 037例,对照人群7 262例。Meta分析结果表明TNF-α基因G308A多态性与MI易感性间的相关性无统计学意义;对MI类型的亚组分析结果显示TNF-α基因G-308A多态性与急性MI显著相关。发表偏倚为轻度。结论:当前证据表明TNF-α基因G-308A基因多态性与MI易感性可能不相关,但是与急性MI患病风险增加有关。Objective Tumor necrosis factor-alpha（ TNF-α） gene G-308 A polymorphism have been used to predict a person＇s susceptibility to myocardial infarction（ MI）,but the results from different studies are still controversial. Hence,we performed a meta-analysis to evaluate the association between them. Methods The relevant data were retrieved in Pub Med,Embase,and CNKI were searched up to April 20,2014. After extracting the data from eligible studies,the meta-analysis was performed by using Comprehensive Meta-Analysis V2 software. Results Compatible 12 publications with 13 case-control studies involving 6 037 cases and 7 262 controls were included in the analysis. The overall results showed that there was no significant association between TNF-α G-308 A polymorphism and MI risk. However,when performing subgroup analysis according to the stage of MI,the results indicated that there was a significant association between TNF-α G-308 A polymorphism and acute MI risk. Publication bias was mild. Conclusion The current evidence showed that the TNF-α G-308 A polymorphism may be not associated with the suceptibility of MI,but with the increased risk of acute MI.

关 键 词：肿瘤坏死因子-Α 多态性 心肌梗死 急性心肌梗死 META分析 

分 类 号：R542.22[医药卫生—心血管疾病]