造血干细胞移植后人巨细胞病毒感染的相关性研究  

Human cytomegalovirus infection and hematogenic stem cell transplantation

作　　者：戴艳[1] 方芳[2] 冯钢[2] 苏贵平[1] 黄来全[1] 蒋艺枝[1] 黄东平[1] 

机构地区：[1]皖南医学院附属弋矶山医院血液内科,安徽芜湖241001 [2]皖南医学院附属弋矶山医院检验科,安徽芜湖241001

出　　处：《皖南医学院学报》2015年第1期36-38,共3页Journal of Wannan Medical College

基　　金：皖南医学院重点培育基金项目(WK2012ZF03)

摘　　要：目的：探讨分析造血干细胞移植（hematopoietic stem cell transplantation,HSCT）后人巨细胞病毒（HCMV）感染与更昔洛韦（ganciclovir,GCV）耐药的发生及与移植类型、移植物抗宿主病（GVHD）等的相关性。方法：2012年3月-2014年4月在我院接受HSCT的患者18例,采用FQ-PCR法监测HCMV-DNA水平。HCMV-DNA阳性患者给予GCV抢先治疗。结果：8例患者发生HCMV感染（44.4%）,其中7例为不全相合无关供体脐血造血干细胞移植（UCBT）者。发生HCMV感染的8例患者中有7人出现GVHD,其中出现Ⅲ度及以上GVHD有5例（71.4%）,均为UCBT者。GCV耐药2例,均为UCBT后。结论：UCBT患者HCMV感染及GCV耐药高,GVHD与HCMV感染有关。Objective： To investigate the incidence of cytomegalovirus（ CMV） infection and ganciclovir（ GCV） resistance after hematopoietic stem cell transplantation（ HSCT）,and the correlation between CMV infection and graft-versus-host disease（ GVHD）. Methods： Eighteen patients undergone HSCT in our hospital were included between March 2012 and April 2014. Real-time fluorescent quantitative PCR（ FQ-PCR） was performed to test the CMV infection in total patients,and patients with positive CMV-DNA were treated with GCV. Results： CMV infection occurred in 8 patients（ 44. 4%）,in whom 7were umbilical cord blood transplantation（ UCBT） from unrelated donors（ 87. 5%,7 /8）. Seven in 8 with CMV infection were complicated with GVHD,in which 5 were infection of grade Ⅲ or over（ 71. 4%,5 /7）. GCV resistance after UCBT occurred in 2. Conclusion： HCMV infection and GCV resistance appear higher in patients after UCBT,and incidence of GVHD is associated with HCMV.

关 键 词：造血干细胞移植 人巨细胞病毒 更昔洛韦 

分 类 号：R457.7[医药卫生—治疗学]