布洛芬热分解及其动力学研究  

Thermal Behavior and Decomposition Kinetics of Ibuprofen

作　　者：郭慧卿[1] 成日青[1] 陈建平[1] 塔娜[1] 齐和日玛[1] 马岚[1] 王来兵[1] 杜艳青[1] 刘粉荣[2] 

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010110 [2]内蒙古大学化学化工学院,内蒙古呼和浩特010021

出　　处：《广州化工》2015年第7期100-102,共3页GuangZhou Chemical Industry

摘　　要：通过布洛芬(ibuprofen)的热分解及其动力学研究,运用简单的热分解动力学方法进行计算分析,求出相关的活化能,指前因子和动力学参数。将布洛芬每个温度范围下的热分解过程分为3个阶段分别进行分析计算,发现每个阶段都满足一级反应方程。从而算出布洛芬热分解过程的活化能,指前因子和相关系数。通过对布洛芬热分解过程的研究,及对布洛芬TG和DTG曲线的研究,得出布洛芬在热分解过程中分为3个阶段,分别进行脱水,C-C键断裂和分子键断裂。并且随着升温速率的提高,布洛芬失重速率会逐渐趋向于温度升高的方向发展,即温度升高,布洛芬最大失重速率越大。To determine thermal decomposing behavior of ibuprofen, the probable mechanism of thermal decomposing reaction was speculated and the kinetic parameters were calculated. Thermal decomposing behavior of ibuprofen was studied in the air by TG-DTG techniques. Four thermal analysis kinetic methods were used to speculate the probable mechanism of thermal decomposing reaction and calculate the kinetic parameters. With ibuprofen＇s activation energy of thermal decomposing with oxygen, the de composing process fit the model function of reaction on surface for shrinking round column. Effecting by the math equation of kinetic compensating, the most probable mechanism of ibuprofen＇s activation energy thermal decomposing reaction with oxygen and the math equation of kinetic compensating effect were speculated. The decomposing process fit the model function of reaction on surface for shrinking round column.

关 键 词：布洛芬 热分析 热分解反应动力学 

分 类 号：TQ31[化学工程—高聚物工业]