糖尿病患者血浆中半乳糖凝集素-3水平的表达  

Expression of plasma galectin-3 in patients with diabetes mellitus

作　　者：尹秋生[1] 施冰[1] 冬兰[1] 毕磊[1] 

机构地区：[1]北京军区总医院干一科,北京100700

出　　处：《中国临床保健杂志》2015年第2期153-154,共2页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨半乳糖凝集素-3(Galectin-3)在糖尿病患者血浆中的表达情况,以及与其他因素的相关性分析。方法对30例糖尿病患者、22例非糖尿病患者(对照组)血浆中的Galectin-3进行测定,比较两组间Galectin-3水平变化,分析Galectin-3与其他因素的相关性。结果糖尿病患者血浆中的Galectin-3水平[(17.95±2.61)μg/L]显著高于对照组[(15.59±2.39)μg/L],差异有统计学意义(P<0.01)。Galectin-3与空腹血糖(FBG)有显著地相关性(P<0.01),与糖尿病病程(DD)、钠尿肽(BNP)有明显相关性(P<0.05)。结论 Galectin-3作为重要的炎症调节因子,可能在糖尿病的发生发展中起着重要的调节作用。Objective To analyze the plasma galectin-3 level in patients with diabetes mellitus and its relevant risk factors.Methods Thirty patients with diabetes mellitus served as study group and twenty-two individuals without diabetes mellitus served as control group were enrolled in this study.The levels of plasma Galectin-3 were measured and compared between the two groups.The correlation between plasma galectin-3 and other risk factors were analyzed.Results Levels of plasma Galectin-3 was（17.95 ± 2.61） μg/L in study group,and（15.59 ± 2.39） μg/L in control group.Difference in levels of plasma galectin-3 between the two groups was significant（P 0.01）.Pearson analysis showed that plasma galectin-3had significant correlation with fasting blood glucose,duration of diabetes,and B-type natriuretic peptide（P 0.01 or P 0.05）.Conclusion As an important regulation factor of inflammation,galectin-3 may play a role in the pathogenesis of diabetes mellitus.

关 键 词：糖尿病 半乳糖凝集素3 血糖 

分 类 号：R587.1[医药卫生—内分泌]