茚达特罗对COPD患者日常活动影响的研究  

Study on influence of Indacaterol on daily activities of patients with COPD

作　　者：段玲[1] 陈章[1] 肖贞良[1] 

机构地区：[1]成都军区总医院呼吸科二病区,成都610083

出　　处：《西南国防医药》2015年第4期369-372,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的研究茚达特罗对慢性阻塞性肺疾病(COPD)患者的治疗效果及日常活动的影响。方法采取随机对照方法,将129例中度COPD患者分为3组,每组43例,分别每日单次吸入150μg茚达特罗(茚达特组)、安慰剂(空白对照组)、18μg噻托溴铵(噻托溴铵组),疗程均为3 w。治疗3 w后,采用身体体积描记法及肺活量检测评估肺功能,多感官臂带记录评估患者活动量的改变。结果治疗3 w后,茚达特罗组最大吸气量为2.69 L,显著大于噻托溴铵组及空白对照组(P<0.05);与安慰剂相比,茚达特罗和噻托溴铵均能显著改善肺功能相关指标(P<0.05);对每日步行数、每日步行时间、平均活动水平进行比较,茚达特罗组均优于噻托溴铵组及空白对照组(P<0.05);3组间不良反应无统计学差异(P>0.05)。结论每日单次吸入150μg茚达特罗能够缓解中度COPD患者肺的过度充气(肺气肿),对患者日常活动能力的改善也有积极作用。Objective To study the curative effect and influence of Indacaterol on daily activities of patients with chronic obstructive pulmonary disease （COPD）. Methods 129 patients with COPD were randomly divided into three groups （ n = 43 per group）, and they were administered with 150 μg of Indacaterol （Indacaterol group）, placebo （blank control group）, and 18 μg of tiotropium bromide （tiotropium bromide group） once every day. The treatment courses were all three weeks. After one treatment course, body plethysmography and vital capacity were used to evaluate the pulmonary function, and multi-sensory arm band was used to record and evaluate the change of activities of the patients. Results After one treatment course, the maximum inspiratory volume in the Indacaterol group was 2.69 L, significantly greater than those in the tiotropium bromide group and blank control group （P 〈 0.05）; compared with placebo, Indacaterol and tiotropium bromide can significantly improve the related indexes of pulmonary function （P 〈 0.05） ; in terms of daily walking, walking time, and the average daily activity levels, the lndacaterol group was better than the tiotropium bromide group and blank control group （P 〈 0.05） ; there was no significant difference in adverse reactions among the three groups （P 〉 0.05）. Conclusion 150 Ixg of Indacaterol administered once every day can alleviate the pulmonary hyperinflation （emphysema） of patients with moderate COPD, and can positively improve the daily activities of the patients.

关 键 词：慢性阻塞性肺疾病 茚达特罗 噻托溴铵 日常活动 

分 类 号：R563[医药卫生—呼吸系统]