黄芪注射液/华蟾素注射液联合右丙亚胺对阿霉素相关性心脏毒性的保护作用  

Protective effects of Astragalus injection/Huachansu injection combined with dexrazoxane against adriamycin related cardiac toxicity

作　　者：罗仁峰[1] 刘敏[2] 张苏川[2] 

机构地区：[1]江汉大学第二附属医院肿瘤科,湖北武汉430050 [2]江汉大学附属医院心内科,湖北武汉430015

出　　处：《中国医院药学杂志》2015年第7期629-632,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨黄黄芪注射液/华蟾素注射液联合右丙亚胺对阿霉素相关性心脏毒性的保护作用,并与单用右丙亚胺对比研究。方法:120例采用含阿霉素化疗方案首次治疗的恶性肿瘤患者随机分为:A组:右丙亚胺组;B组:右丙亚胺与黄芪注射液联合治疗;C组:右丙亚胺与华蟾素注射液联合治疗组;D组:右丙亚胺与黄芪注射液及华蟾素注射液联合治疗组(每组各30例)。A组常规化疗前给予右丙亚胺静脉输注,B组常规化疗前给予右丙亚胺与黄芪联合治疗,C组常规化疗前给予右丙亚胺与华蟾素联合治疗,D组常规化疗前给予右丙亚胺、黄芪及华蟾素联合治疗,共4个周期。比较4组患者治疗前后心电图、肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白Ⅰ(cTnⅠ),左室舒张末期内径(LVIDD),左射血分数(EF)。结果:经4个周期治疗后,D组无论是心电图异常发生率还是CK-MB、cTnⅠ、LVIDD、EF与另三组比较差异均有显著性(P<0.05);而A、B、C3组间患者的心电图异常发生率、CK-MB、cTnⅠ、LVIDD、EF无显著性差异(P>0.05)。结论:黄芪和华蟾素注射液联合右丙亚胺可减低阿霉素所致心脏毒性作用,优于单用右丙亚胺。OBJECTIVE To investigate the protective effects of Astragalus injection/Huachansu injection combined with dexrazoxane against adriamycin related cardiac toxicity,and compare with the results obtained by singly using dexrazoxane.METHODS A total of 120 patients with malignant tumors treated by doxorubicin as the first chemotherapy were randomly divided into：group A：dexrazoxane group;group B：dexrazoxane combined with Astragalus;group C：dexrazoxane combined with Huachansu injection;group D：dexrazoxane combined with Astragalus and Huachansu injections;each group had 30 patients.Dexrazoxane injection as administered to patients in group A received before routine chemotherapy;dexrazoxane combined with Astragalus injection to patients in group B;dexrazoxane combined with Huachansu injection to patients in group C;and dexrazoxane combined with Astragalus and Huachansu injections to patients in group D.Electrocardiogram,creatine kinase isoenzyme MB（CK-MB）and cardiac troponin I（cTn I）,brain natriuretic peptide precursor NT-proBNP,left ejection fraction（EF）were compared in patients between the four groups before and after therapy.RESULTS After treatment,group D had significantly different abnormal ECG,CK-MB,cTnI,LVIDD and EF compared with the other three groups（P〉0.05）.While groups B,C and A had no significantly different abnormal ECG rate,CK-MBm cTnI,LVIDD and EF（P〈0.05）.CONCLUSION Astragalus and cinobufotalin injections combined with dexrazoxane may reduce the adriamycin induced cardiotoxicity,superior to the single use of dexrazoxane.

关 键 词：黄芪注射液 华蟾素注射液 右丙亚胺 阿霉素 心脏毒性 保护作用 

分 类 号：R285[医药卫生—中药学]