Structural elucidation of two new megastigmane glycosides from the leaves of Aquilaria sinensis  

作　　者：SUN Jian XIA Fang WANG Shu WANG Ke-Yuan CHEN Jin-Ming TU Peng-Fei 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center [2]Tai Ji Pharmaceutical Research Institute [3]Guangdong Junyuan Pharmaceutical Co., Ltd.

出　　处：《Chinese Journal of Natural Medicines》2015年第4期290-294,共5页中国天然药物（英文版）

基　　金：supported by Special Program for New Drug Innovation of the Ministry of Science and Technology,China(2009ZX311-004,2009ZX0308-004)

摘　　要：The present study was designed to determine the chemical constituents and identify new components of the leaves of Aquilaria sinensis （Lour.） Gilg. The compounds were isolated and purified by repeated silica gel, Sephadex LH-20, and ODS column chromatography and their structures were elucidated by NMR and HR-ESI-MS spectrometry. Eight megastigmane glycosides and two cucurbitacins were isolated and identified as （95） megastigma-4,7-diene-2,3,9-triol 9-O-β-D-glucopyranoside （1）, （9S） megastigma-4（13）,7-diene-3,6,9-triol 9-O-β-D-glucopyranoside （2）, macarangloside D （3）, corchoionoside C （4）, staphylionoside H （5）, （＋） 3-oxo-a-ionol-β-D-glucopyranoside （6）, （-） 3-oxo-α-ionol-β-D-glucopyranoside （7）, citroside B （8）, 2-O-β-D-glucopyranosyl cucurbitacin I （9）, bryoamaride （10）. Compounds 1 and 2 were newly identified megstigmane glucosides and reported from this genus for the first time.The present study was designed to determine the chemical constituents and identify new components of the leaves of Aquilaria sinensis(Lour.) Gilg. The compounds were isolated and purified by repeated silica gel, Sephadex LH-20, and ODS column chromatography and their structures were elucidated by NMR and HR-ESI-MS spectrometry. Eight megastigmane glycosides and two cucurbitacins were isolated and identified as(9S) megastigma-4,7-diene-2,3,9-triol 9-O-β-D-glucopyranoside(1),(9S) megastigma-4(13),7-diene-3,6,9-triol 9-O-β-D-glucopyranoside(2), macarangloside D(3), corchoionoside C(4), staphylionoside H(5),(+) 3-oxo-α-ionol-β-D-glucopyranoside(6),(–) 3-oxo-α-ionol-β-D-glucopyranoside(7), citroside B(8), 2-O-β-D-glucopyranosyl cucurbitacin I(9), bryoamaride(10). Compounds 1 and 2 were newly identified megstigmane glucosides and reported from this genus for the first time.

关 键 词：Aquilaria sinensis （Lout.） Gilg Megstigmane glucosides 

分 类 号：R284[医药卫生—中药学]