雄激素受体(CAG)_n基因多态性与多囊卵巢综合征相关性的Meta分析  

Meta-analysis of relationship between androgen receptor CAG repeats length polymorphism and the polycystic ovary syndrome

作　　者：余瑞梅 邱娜璇[1] 陈春敏[1] 

机构地区：[1]厦门大学附属第一医院妇产科,361003

出　　处：《中国妇产科临床杂志》2015年第2期145-149,共5页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的评价雄激素受体（androgen receptor,AR）（CAG）n基因多态性与多囊卵巢综合征（polycystic ovary syndrome,PCOS）易感性的相关性。方法检索Pubmed、Embase、CNKI、VIP、万方数据库,英文检索词为androgen receptor,polycystic ovarian syndrome,中文检索词为雄激素受体和多囊卵巢综合征,收集有关AR（CAG）n基因多态性与PCOS易感性的病例对照研究,进行Meta分析。结果共纳入12篇文献,PCOS组1 697例,对照组（健康女性）1 984例。Meta分析结果显示,PCOS组与对照组间AR（CAG）n重复序列长度比较,差异无统计学意义[标准化均数差（SMD）=-0.05,95%CI：-0.19-0.08,P=0.440]。PCOS患者中,高雄激素血症（hyperandrogenism,HA）患者与非HA患者间AR（CAG）n重复序列长度比较,差异无统计学意义（SMD=0.56,95%CI：-0.13-1.25,P=0.110）。结论 AR（CAG）n基因多态性可能与PCOS及其并发的高雄激素血症的发生无关联。Objective To evaluate the correlation between the genetic polymorphism of CAG repeats length and the susceptibility of polycystic ovary syndrome（PCOS）.Methods Databases including the Pubmed,Embase,CNKI,VIP,Wanfang were searched to collect the case-control studies on the relationship of androgen receptor CAG repeats length polymorphism with PCOS.The data was analyzed by Meta-analysis.Results 12 studies were selected,which included 1 697 PCOS cases and 1 984 control samples.The result of Meta-analysis showed that there had no significant differences between PCOS cases and controls in the mean length of androgen receptor CAG repeats（SMD=-0.05,95%CI-0.19-0.08,P=0.44）.The mean length of androgen receptor CAG repeats in hyperandrogenic patients had no significant different with nonhyperandrogenic patients in PCOS cases（SMD=-0.56,95%CI-0.13-1.25,P=0.11）.Conclusion The androgen receptor CAG repeats length polymorphism has no collection with both PCOS and hyperandrogenic.

关 键 词：雄激素受体 多囊卵巢综合征 基因多态性 META分析 

分 类 号：R711.75[医药卫生—妇产科学]