可吸收防粘连液对大鼠实验性腹壁粘连的抑制作用  

Inhibitory Effect of Absorbable Anti-adhesion Fluid on Experimental Abdominal Adhesions in Rats

作　　者：付凌云[1,2] 刘小红[1,2] 文波[1,2] 肖可 徐旖旎[1] 沈祥春[1,2] 

机构地区：[1]贵阳医学院天然药物资源优效利用重点实验室,贵州贵阳550004 [2]贵阳医学院中药药理教研室,贵州贵阳550004 [3]贵州金玖生物技术有限公司,贵州贵阳550005

出　　处：《贵阳医学院学报》2015年第3期237-240,共4页Journal of Guiyang Medical College

基　　金：贵州省工业攻关计划[黔科合GY字(2010)3063号]

摘　　要：目的:观察可吸收防粘连液对大鼠实验性腹壁粘连的抑制作用。方法:60只SD大鼠随机分为生理盐水组(A组)、医用透明质酸钠凝胶组(B组)、可吸收防粘连液组(C组)3组,每组20只,制作大鼠腹壁缺损/盲肠刮伤模型,在造模后第7和第14天处死大鼠,观察粘连分级积分、解剖学、病理组织学改变。结果:可吸收防粘连液显著抑制大鼠实验性腹壁粘连,降低粘连分级积分;减少炎细胞浸润和炎性肉芽组织增生,浆膜层组织变性较轻。结论:可吸收防粘连液在一定程度抑制术后粘连。Objective： To investigate the inhibitory effect of absorbable anti-adhesion fluid on experimental abdominal adhesion in rats. Methods： Sixty SD rats were randomly divided into 3 groups as following： normal saline group（ group A）,medical sodium hyaluronate gel group（ group B）,and absorbable anti-adhesion fluid group（ group C）. The abdominal wall defect and cecal abrasion model was establiehsed. After 7 d and 14 d of operation,the rats were sacrificed and the following indexes including adhesion classification, gross anatomy observation, and histopathologic examination were checked. Results： The adhesion classification was significant decreased in group C,there were significant differences compared to group A（ P〈0. 05）. Histopathological examination confirmed that absorbable anti-adhesion fluid could attenuate inflammatory cell infiltration,granulation tissue proliferation,and serosal tissue degeneration. Conclusions： Absorbable anti-adhesion fluid can inhibit adhesion after operation.

关 键 词：可吸收防粘连液 大鼠 Sprague-Dawley 模型 动物 粘连 腹壁 病理学 

分 类 号：R285[医药卫生—中药学] R619.9[医药卫生—中医学]