BMI及LDL-C水平与冠脉慢血流的相关性研究  

Correlation between LDL-C, BMI and Coronary Slow Flow

作　　者：周叶[1] 彭利[1] 李建华[1] 晏沐阳[1] 

机构地区：[1]解放军总医院心内科老年心血管病研究所,北京100853

出　　处：《现代生物医学进展》2015年第7期1201-1204,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81073093)

摘　　要：目的:探讨低密度脂蛋白胆固醇及身高体重指数与冠状动脉慢血流现象(Coronary slow flow phenomenon,CSFP)的相关性。方法:在我院2013年上半年因不典型胸痛行冠脉造影术患者中,选取冠脉官腔无明显狭窄(<40%)且至少一支冠脉根据校正的TIMI血流分级方法被评为慢血流的患者进入慢血流组(CSFP组)79例,选取同期无明显狭窄且血流速度正常的患者71例为对照组,对两组入院各项常规检查检验指标进行分析,筛选导致冠脉慢血流的危险因素。结果:在两组比较中,CSFP组的慢血流组吸烟率、身体质量指数(Body Mass Index,BMI)、甘油三酯(Triglyceride,TG)、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)、尿酸(Uric acid,UA)水平明显高于对照组;亚组分析中显示BMI、LDL-C水平随受累血管数量增多呈上升趋势,且具有统计学意义;经回归分析,显示BMI、LDL-C水平的升高对冠脉慢血流的发生有显著影响,且与冠脉血流速度(帧数)呈正相关。结论:BMI、LDL-C水平与冠脉慢血流的发病的密切相关。Objective： The aim of this research is to study the correlations between LDL-C, BMI and coronary slow flow phe- nomenon （CSFP）. Methods： The 150 patients with chest pain, who were underwent coronary angiography, were divided by corrected TIMI frame count（CSFP was defined as flame count 〉27） into CSF group（79） and control group（71）. Body mass index （BMI）, age, gender, his- tory of smoking, hypertension, diabetes and hyperlipidemia were recorded and the total cholesterol （TC）, triglyceride （TG）, Low-density lipoprotein（LDL-C）, high-density lipoprotein （HDL-C）, uric acid （UA）, creatinine （Cr）, left ventricular ejection fraction （EF）, Systolic blood pressure（SBP） and Diastolic blood pressure（DBP） were measured on admission. Results： The smoking rate, BMI, TG, LDL-C, UA was significantly higher in the patients with the CSF group than the control group. BMI, LDL-C in the CSF group increased significantly with increasing vessel involvement. The logistic regression analysis showed that BM! and LDL-C were the influence factor for coronary slow flow, and were positively correlated with CSFP. Conclusions： CSFP is associated with BMI and LDL-C.

关 键 词：冠状动脉慢血流现象 低密度脂蛋白胆固醇 身体质量指数 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]