生物活性透明质酸治疗激光所致皮肤创口炎症的临床疗效观察  

Observation on the Clinical Efficacy of Bioactive Hyaluronic Acid Fragment in the Treatment of Laser Induced Skin Wound

作　　者：沈明强[1] 刘鑫[1] 魏晨 席丽艳[3] 惠觅宙[1,2] 

机构地区：[1]杭州师范大学,浙江杭州310000 [2]杭州安瑞普生物制品研究有限公司,浙江杭州310020 [3]中山大学孙逸仙纪念医院,广东广州510120

出　　处：《现代生物医学进展》2015年第7期1300-1303,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨生物活性透明质酸治疗激光所致皮肤创口炎症的临床疗效。方法:选择我院收治的40例激光皮肤除斑患者为研究对象,按就诊顺序将其分为实验组和对照组。实验组20例患者采用生物活性透明质酸涂抹激光治疗后的皮肤伤口,对照组20例患者采用30分冰袋冷敷皮肤激光治疗后的皮肤伤口,观察和比较两组患者伤口第1-7天的的红肿痛的改善情况。结果:(1)疼痛症状的改善情况:实验组第1天的显效率0%,有效20例,总有效率100%;对照组第1天的显效率0%,有效20例,总有效率100%,两组比较无统计学差异(P>0.05)。(2)红肿的改善情况:实验组第1天显效20例,总有效率为100%;对照组第1天显效0例,有效20,总有效率为100%,两组总有效率比较无统计学差异(P>0.05),但实验组的显效率明高于对照组,差异具有统计学意义(P<0.01)。结论:生物活性透明质酸涂抹可以有效控制皮肤伤口炎症引发的红肿痛,且临床效果明显优于冰袋冷敷,方便可行,值得推广。Objective： The aim of this study was to investigate clinical effect of topical application of bioactive hyaluronic acid fragment to regulate skin wound induced inflammatory reaction. Methods： Total 40 patients were divided into two groups. Experimental group and control group, each with 20 patients. Bioactive hyaluronic acid fragment was topically used to treat laser treatment induced acute facial skin wound in order to control inflammatory reaction and healing in the experimental group. Then, wound inflammatory reac- tion including pain, redness, and swelling was monitored. Cold compress of 30 minutes was used in the control group. Results：（1） Inflam- matory pain： Both 20 patients in experimental group and control group all feel mild pain after the treatment of cold compress（P〉0.05）. （2） Clinical sign： wound redness and swelling in 20 patients of experimental group were inhibited significantly better than that of control group （P〈0.01）. Conclusion： Topical application of bioactive hyaluronic acid fragment significantly inhibits skin wound inflammatory re- action and does not affect healing process, suggesting its clinical role to replace cold compress and positively regulate wound inflamma- tion and healing.

关 键 词：生物活性透明质酸 内毒素拮抗剂 皮肤创口 炎症 

分 类 号：R75[医药卫生—皮肤病学与性病学] R969[医药卫生—临床医学]