环境雌激素双酚A的研究进展  

The Research Progress of Environmental Estrogen Bisphenol A

作　　者：李楠[1] 范添博 田义军[1] 郭婧[1] 吴琼[1] 

机构地区：[1]哈尔滨工业大学,生命科学与技术学院,黑龙江哈尔滨150080

出　　处：《现代生物医学进展》2015年第7期1353-1356,共4页Progress in Modern Biomedicine

基　　金：国家重点实验室项目(2010TS05)

摘　　要：环境荷尔蒙是现代生命科学领域研究的热点之一,如今越来越多的人开始关注这一话题。在我们的生活环境中充斥着各种化学有毒试剂,其中,有一类物质能够模拟或抑制内分泌激素的活动,我们称之为内分泌干扰物。内分泌干扰物有能力改变内分泌系统的结构和功能。双酚A作为一种环境雌激素,属于内分泌干扰物的一种。双酚A被广泛应用于聚碳酸酯塑料和环氧树脂的制造。双酚A具有弱雌激素效应,能够与雌激素受体结合,引起内分泌系统的应答。目前的研究表明,双酚A会透过血胎屏障影响到胚胎发育,会对神经内分泌系统、肝组织功能以及生殖器的发育造成损伤。本文主要综述了环境雌激素双酚A在小鼠发育阶段所引起的诸多不利影响,并对环境荷尔蒙未来的研究方向进行了展望。Environmental hormones is one of the hot spots in the modern life science research. Nowadays more and more people begin to pay attention to this topic. It is filled with a variety of chemical toxic reagents in our living environment. Among them, there＇s a class of substances which can simulate or inhibit hormone activity, called endocrine disruptors. Endocrine disruptors have the ability to change the structure and function of the endocrine system. Bisphenol A is an environmental estrogen, which belongs to one of endocrine disruptors. Bisphenol A is widely used in the manufacture of polycarbonate plastic and epoxy resins. Bisphenol A has a weak estrogenic effect and can bind to estrogen receptors, causing the endocrine system response. The present study shows that bisphenol A affect embry- onic development cross the blood placental barrier and damage the neuroendocrine system, liver function and reproductive development. This paper summarizes many adverse effects caused by the environmental estrogen bisphenol A during developmental stage in mice and discusses the research direction of environmental hormones in the future.

关 键 词：环境荷尔蒙 内分泌干扰物 双酚A 雌激素 

分 类 号：Q95-3[生物学—动物学] Q56